Over several centuries, oral dosage forms have remained incomparably superior to alternative medication delivery methods. For its ease of formulation and administration, stability, excellent rate patient compliance, the route is preferred. Gastric emptying has been a major drawback for drugs that stay very short period in stomach. An innovative method gastro-intestinal retention allows form gas...

This study investigated the birth of a brownbanded bamboo shark Chiloscyllium punctatum at the Steinhart Aquarium. Genetic analyses suggest this is the longest documented case of sperm storage for any species of shark (45 months).

conclusions algino-pectinate mucoadhesive formulations exhibited promising properties of a sustained release form for piroxicam and provided distinct tissue protection in stomach. objective the purpose of this research was to decrease gastric side effects of piroxicam by formulating microspheres of alginate and algino-pectinate beads of the drug. materials and methods ionotropic gelation was us...

Generalized gut transit abnormalities are observed in some diabetics with gastroparesis. Relations of gastric emptying abnormalities to colon contractile dysfunction are poorly characterized. We measured colon transit and contractility using wireless motility capsules (WMC) in 41 healthy subjects, 12 diabetics with gastroparesis (defined by gastric retention >5 hours), and 8 diabetics with norm...

Pylorospasm and gastric retention in man have been regarded as important factors in the genesis of peptic ulcers (1) but the factors controlling pyloric function and gastric evacuation have continued to remain more or less obscure (2). Attempts to produce pylorospasm in dogs do not seem to have met with success (lb). Our own study of the subject began in an at tempt to determine whether the gas...

The effects of the nitric oxide donor nitroglycerin on gastric emptying and antropyloroduodenal motility were evaluated in nine healthy male subjects (ages 19-36 yr). Antropyloroduodenal pressures were recorded with a manometric assembly that had nine side holes spanning the antrum and proximal duodenum and a pyloric sleeve sensor; gastric emptying was quantified scintigraphically. In each subj...

Floating matrix tablets or stomach specific drug delivery systems are designed to prolong the gastric residence time after oral administration, at a particular site and controlling the release of drug, especially useful for achieving controlled plasma level as well as improving bioavailability. Due to low gastric retention time, the bioavailability of acyclovir is low as the large portion of dr...

Current pharmaceutical situation focuses on the preparation of gastro-retentive floating drug delivery system (GRFDDS). This systems has gained noteworthy interest in past decades. These are low density that float over gastric contents and remain buoyant stomach for a prolonged period time without affecting emptying rate. GRFDDS is used to delay residence stomach. The controlled retention solid...

In the present investigation a gas powered tablets (floating tablets) of Captopril were prepared to increase the gastric retention time in order to improve the therapeutic effect of the drug by increasing its bioavailability. Captopril is antihypertensive drug, it is soluble in water; its maximum absorption is from the stomach and upper part of the intestine. The Gas powered tablets were prepar...

BACKGROUND Nanotechnology-based drug delivery systems have been widely used for oral and systemic dosage forms delivery depending on the mucoadhesive interaction, and keratin has been applied for biomedical applications and drug delivery. However, few reports have focused on the keratin-based mucoadhesive drug delivery system and their mechanisms of mucoadhesion. Thus, the mucoadhesion controll...