In this study, albino Wistar rats were placed on normal rats chow + drinking water and/or 500mg/kg, 1000mg/kg body weight of the Ocimum gratissimum extract orally, once daily for 28 days and gastric acid, mucus and ulcers determined. All the rats received normal rat chow + drinking water ad libitum for 28 days. Gastric acid, mucus secretion and ulcer scores were determined with standard procedu...

Ghrelin is a gastric peptide hormone that controls appetite and energy homeostasis. Plasma ghrelin levels rise before a meal and fall quickly thereafter. Elucidation of the regulation of ghrelin secretion has been hampered by the difficulty of directly interrogating ghrelin cells diffusely scattered within the complex gastric mucosa. Therefore, we generated transgenic mice with ghrelin cell exp...

Studies of basal and histamine-stimulated gastric acid secretion were performed in 42 controls, in 133 patients with duodenal ulceration, in 57 patients with gastric ulceration, in 13 patients with both duodenal and gastric ulceration, and in 20 patients with gastric carcinoma. All these subjects were Chinese. Statistical analysis of the results showed that all clinical groups differed from the...

Applied potential tomography (APT) is a new, non-invasive technique that can yield sequential images of changes in the resistivity of gastric contents. Studies were performed to investigate the application of APT to measure gastric acid secretion. Experiments in 20 normal volunteers showed that changes in gastric resistivity were closely correlated with changes in the volume (r = 0.80), the aci...

The effect of peptide histidine valine-42 (PHV-42) on gastric acid secretion was studied in man. PHV-42 was infused into 5 healthy volunteers at a dose of 10 pmol/kg/min. This dose caused a significant stimulation of basal gastric acid and potassium output. There were no significant changes in circulating gastrin throughout the infusion. In 2 subjects with a background of submaximal pentagastri...

1 Characterization of the ,B-adrenoceptors mediating inhibition of gastric acid secretion in the conscious Heidenhain pouch dog has been investigated by determination of the effects of propranolol, (+)-propranolol, practolol and H35/25 on salbutamol and isoprenaline-induced inhibition of gastric acid secretion. 2 The gastric antisecretory effect of salbutamol was significantly blocked by propra...

Excessive gastric acid secretion plays an important role in the pathogenesis of peptic ulcers. Dexamethasone, a widely used drug, is known to stimulate gastric acid secretion and increase the incidence of peptic ulcers. However little is known about the mechanism of the dexamethasone's effect on parietal cells. The present study was performed to investigate the contribution of the phosphatidyli...

The effect of intraduodenal acid on pentagastrin-stimulated gastric secretion has been investigated in 12 normal subjects and 23 patients with chronic duodenal ulceration. Plasma secretin levels were monitored during each test using a highly sensitive radioimmunoassay. Significant inhibition of gastric secretion occurred in the normal subjects and duodenal ulcer patients. A significant rise in ...

MOODY, FRANK G. Oxygen consumphn during thiocyanate irhibition of gastric acid secretion in dog. Am. J, Physiol. 2 15( 1) : 127-131. 1968.-The relationship between oxygen c&sumption, blood flow, and acid secretion was studied in exteriorized gastric se gments of the dog during histamine and thiocyanate administration. Acid secretion and oxygen consumption demonstrated a highly significant linea...

EDITORIAL SYNOPSIS The possible relationship between hyperparathyroidism and peptic ulcer has stimulated renewed interest in the relationship between calcium and gastric secretion. This study shows that in patients with primary hyperparathyroidism the basal secretion of acid was raised but the augmented histamine secretion was essentially normal. The basal secretion was lowered by parathyroidec...