Geniposide (GE) is the extraction and purification of iridoid glycosides from the Gardenia jasminoides Ellis, which is a promising anti-inflammatory drug, but its mechanism of actions on rheumatoid arthritis (RA) has not been clarified. This study investigated the molecular mechanism behind GE reduced the high permeability of fibroblast-like synoviocytes (FLSs) derived from SD rats with adjuvan...

The effects of aqueous leaves extract of the Gardenia ternifolia plant (ALEGTP) was investigated against carbon tetrachloride (CCl4) induced hepatotoxicity in rats. Thirty albino rats were used for the experiment and grouped into six (n=5); group 1 and 2 were normal and control respectively. Group 3 was pretreated with silymarin while group 4, 5 and 6 were pretreated with 100, 200 and 400 mg/kg...

Gardenia plants have long been used as traditional medicines in various countries including Thailand. In this study, two new 3,4-seco-cycloartane triterpenes, sootependial (1) and sootepenoic acid (2), were isolated from bud exudate of G. sootepensis, together with five known compounds. Their structures were elucidated on the basis of spectroscopic data. Sootependial (1) showed potent cytotoxic...

Geniposide (GE), an iridoid glycoside compound derived from Gardenia jasminoides Ellis fruit, is known to have anti-inflammatory and immunoregulatory activities. The aim of this study was to investigate the protective mechanism of GE in the regulation of the mitogen-activated protein kinase (MAPK) signalling pathway and the cross-talk among the MAPK signalling pathway in fibroblast-like synovio...

This paper presents the Graph Analytics Repository for Designing Next-generation Accelerators (GARDENIA), a benchmark suite for studying irregular algorithms on massively parallel accelerators. Existing generic benchmarks for accelerators have mainly focused on high performance computing (HPC) applications with limited control and data irregularity, while available graph analytics benchmarks do...

Abstract Background Hereditary ataxia (HA) represents a group of genetically heterogeneous neurodegenerative diseases caused by dysfunction the cerebellum or disruption connection between and other areas central nervous system. Phenotypic manifestation HA includes unsteadiness stance gait, dysarthria, nystagmus, dysmetria complaints clumsiness. There are no specific treatments for HA. Managemen...