Inspired by the combination of unique structure and potent bioactivities exhibited by several family members of the caged Garcinia xanthones, we developed a synthesis of simplified analogues that maintain the overall caged motif. The caged structure of these compounds was constructed via a site-selective Claisen/Diels-Alder reaction cascade. We found that the fully substituted caged structure, ...

Benzophenones from natural sources and those of synthetic analogues present several reports of potent biological properties, and Guttiferone A represents a promising medicinal natural compound with analgesic and gastroprotective profiles. Considering that there are no reports that assess the genetic toxicity of Guttiferone A, the present study was undertaken to investigate the genotoxic potenti...

A UPLC-PDA-QTOFMS-guided isolation strategy was employed to screen and track potentially new compounds from Garcinia oblongifolia. As a result, two new prenylated xanthones, oblongixanthones D and E (1-2), six new prenylated benzoylphloroglucinol derivatives, oblongifolins V-Z (3-7) and oblongifolin AA (8), as well as a known compound oblongifolin L (9), were isolated from the EtOAc-soluble fra...

The Garcinia genus belonging to the Clusiaceae family (Guttiferae) has been reported be a rich source of polyisoprenylated benzophenones, xanthones and biflavonoids with various biological activities. fagraeoides A.Chev is an evergreen hardwood tree found only in north provinces Viet Nam Guangxi province China. Its stem bark leaves have used Vietnamese traditional medicine for treatment malaria...

The in vitro antitumour-promoting, cytotoxic, and antioxidant activities of two ester derivatives of garcinia acid, that is, 2-(butoxycarbonylmethyl)-3-butoxycarbonyl-2-hydroxy-3-propanolide (1) and 1',1''-dibutyl methyl hydroxycitrate (2), that had been previously isolated from the fruits of Garcinia atroviridis Griff. ex T. Anders (Guttiferae), were examined. Based on the inhibition of Epstei...

The title compound, C(38)H(50)O(5) {systematic name: 10-(3-hy-droxy-benzo-yl)-2,2,7,7-tetra-methyl-3,6,8-tris-(3-methyl-but-2-en-yl)-3,4,4a,5,6,7-hexa-hydro-4a,8-methano-2H-cyclo-octa-[b]pyran-9,11(8H)-dione}, is a polyisoprenylated benzophenone, isolated for the first time from the fruits of Garcinia indica during our investigation of bioactive compounds from this plant and their large-scale e...

Two hypotheses have been put forward to explain the large accumulation of organic acids in fruits: (a) organic acids are not formed in the fruit, but are translocated from the leaves to the fruits which would act merely as storage organs (1, 2) ; and (b) the presence of the organic acids in fruits is due to the conversion of carbohydrates to organic acids in the fruit vesicles and not to transl...

The objective of our work has been the identification in the bark of Garcinia cambogia (GC) of the HCA that has proven effective in blocking weight increase. The Hydroxycitric Acid (HCA) is a present alimentary acid in some varieties of tropical fruits, between which the Garcinia cambogia Desr. Its effect on the organism is that one to block to the activity of ATPcitrate lyase in charge of the ...

The present work was designed to assess the antibacterial properties of the methanol extracts of some Cameroonian medicinal plants and the effect of their associations with currently used antibiotics on multidrug resistant (MDR) Gram-negative bacteria overexpressing active efflux pumps. The antibacterial activities of twelve methanol extracts of medicinal plants were evaluated using broth micro...

Twenty fruit species representing 12 families were collected from various regions in western Puerto Rico and monitored for the emergence of Anastrepha spp. pupae. We collected 14,154 tephritid pupae from 16 fruit species representing 10 families. The relative infestations of these fruits (pupae per kilogram of fruit) were recorded. Recorded host ranges were not in complete agreement with those ...