Although previous analyses indicate that neocortical neurons originate from the cortical proliferative zone, evidence suggests that a subpopulation of neocortical interneurons originates within the subcortical telencephalon. For example, gamma-aminobutyric acid (GABA)-expressing cells migrate in vitro from the subcortical telencephalon into the neocortex. The number of GABA-expressing cells in ...

We report a signaling mechanism in rats between mother and fetus aimed at preparing fetal neurons for delivery. In immature neurons, gamma-aminobutyric acid (GABA) is the primary excitatory neurotransmitter. We found that, shortly before delivery, there is a transient reduction in the intracellular chloride concentration and an excitatory-to-inhibitory switch of GABA actions. These events were ...

Weak inhibition within visual cortex early in life prevents experience-dependent plasticity. Loss of responsiveness to an eye deprived of vision can be initiated prematurely by enhancing gamma-aminobutyric acid (GABA)-mediated transmission with benzodiazepines. Here, we use a mouse "knockin" mutation to alpha subunits that renders individual GABA type A (GABA(A)) receptors insensitive to diazep...

gamma-aminobutyric acid is the main inhibitory amino acid neurotransmitter in several areas of the brain. measurement of gamma-aminobutyric acid in the brain will help elucidate its metabolic rote and diagnostic value. the liquid chromatography (lc) system consisted of a delivery pump. male rats (150-250g) were used in this study. the brain was rapidly removed from decapitated animals. trie chr...

Abstract This study aimed to screen the lactic acid bacteria (LAB) strain that has high potential in gamma-aminobutyric (GABA) production and antibacterial properties, which could be applied Vietnamese fermented meat ( Nem chua ) fermentation. These bacterial strains were isolated from commercial products stored laboratory. GABA synthesized 18 of LAB MRS media adding 3% MSG was qualitative quan...

Fresh peaches are highly perishable and they deteriorate quickly during low temperature storage which results in losses in nutritional quality. To prevent these adverse effects, peach fruits were treated by dipping with γ-aminobutyric acid (GABA; 2, 4 and 6 mM) immediately after harvest and then stored at 1 °C for 7, 14, 21, and 28 days. Peach fruits treated with GABA exhibited higher flesh fir...

Gamma Aminobutyric Acid (GABA), also known as 4-aminobutyric acid, of which the molecular formula is C4H9NO2, with a relative molecular weight of 103.2. It widely exists in the cells of microorganism, animals and plants, as a kind of neuro-inhibitory transmitter in mammals, a variety of physiological and metabolic activities are involved. It is greatly demanded by the market for the special phy...

Acetylcholine and gamma -aminobutyric acid (GABA) are putative neurotransmitters in the adult vertebrate retina. In this study, cells that coexpress choline acetyltransferase (ChAT) and GABA or glutamic acid decarboxylase (GAD) were investigated in turtle retinas from stage 14 (S14) to adulthood by using a double-labeling immunofluorescence technique. ChAT immunoreactivity was observed at S15 a...

Four sesquiterpenes, beta-selinene, isocurcumenol, nootkatone and aristolone and one triterpene, oleanolic acid were isolated from the ethylacetate fraction of the rhizomes of Cyperus rotundus and tested for their ability to modulate gamma-aminobutyric acid (GABA(A))-benzodiazepine receptor function by radioligand binding assays using rat cerebrocortical membranes. Among these compounds, only i...