background: the ventral tegmental area (vta) is well known for its role in cardiovascular control. it is demonstrated that about 20-30% of the vta neurons are gabaergic though their role in cardiovascular control is not yet understood. this study is carried out to find the effects of gaba a and gaba b receptors on cardiovascular response of the vta. methods: experiments were performed on uretha...

Social anxiety disorder (SAD) is the one of the most common anxiety disorders. Despite its high prevalence, the disorder is still considerably undiagnosed and untreated. The disease places a massive burden on patient’s lives, affecting not only their social interactions but also their educational and professional activities, thereby constituting a severe disability. γ-aminobutyric acid (GABA) s...

γ-Aminobutiric acid (GABA), the major inhibitory neurotransmitter in the central nervous system is activated by the antispastic and muscle relaxant agent, Baclofen, which is a lipophilic derivative of GABA. Because of its biological and pharmacological importance, there are several reports in the literature about the synthesis of baclofen since 1962. In this study baclofen was easily synthesize...

g -Aminobutiric acid (GABA), the major inhibitory neurotransmitter in the central nervous system has two major receptor subtypes (GABAA and GABAB). GABAB receptors are activated by the antispastic and muscle relaxant agent, Baclofen, which is a lipophilic derivative of GABA. Since 1962 several strategies have been reported for the synthesis of baclofen.In this study an approach has been made to...

n-phthaloyl gaba was administrated daily (50 mg/kg body weight-i.p) to wistar rats for 21 days and circadian rhythms of thiobarbituric acid reactive substances (tbars) and antioxidants such as reduced glutathione (gsh), catalase (cat) and superoxide dismutase (sod) were studied under constant light (ll) conditions. delayed acrophase of tbars and advanced acrophase of antioxidants (gsh, cat and ...

Previous articleNext article No AccessNormativity, Epistemic Rationality, and Noisy Statistical EvidenceBoris Babic, Anil Gaba, Ilia Tsetlin, Robert WinklerBoris Babic Search for more articles by this author , Gaba Tsetlin Winkler PDFPDF PLUS Add to favoritesDownload CitationTrack CitationsPermissionsReprints Share onFacebookTwitterLinkedInRedditEmail SectionsMoreDetailsFiguresReferencesCited T...

In this paper, we present an additional, new cage-GABA compound, called 4-amino-1-(4′-dimethylaminoisopropoxy-5′,7′-dinitro-2′,3′-dihydro-indol-1-yl)-1-oxobutane-γ-aminobutyric acid (iDMPO-DNI-GABA), and currently, compound is the only photoreagent, which can be applied for GABA uncaging without experimental compromises. By a systematic theoretical design successful synthesis of several compoun...

Background: The ventral tegmental area (VTA) is well known for its role in cardiovascular control. It is demonstrated that about 20-30% of the VTA neurons are GABAergic though their role in cardiovascular control is not yet understood. This study is carried out to find the effects of GABA A and GABA B receptors on cardiovascular response of the VTA. Methods: Experiments were performed on uretha...

Intracellular recordings were made from neurons in rat dorsal raphe in the slice preparation maintained at 37 degrees C. The single-electrode voltage-clamp method was used to measure membrane currents at potentials more negative than rest (-60 mV). Three types of inward rectification were observed: 2 in the absence of any drugs and the third induced by 5-HT 1 and GABA-B receptor agonists. In th...