نتایج جستجو برای: g csf mpo pge2
تعداد نتایج: 471343 فیلتر نتایج به سال:
OBJECTIVE To investigate potential associations between the -463 G/A myeloperoxidase (MPO) promoter polymorphism and susceptibility to, and clinical expression of, Behçet's disease (BD). METHODS One hundred and seventy-five Italian patients who satisfied the International Study Group criteria for BD and 235 healthy age- and sex-matched blood donors were genotyped for the -463 G/A promoter pol...
In acute leukaemia, the maturation of the malignant cells is arrested and the cells merely proliferate. In the recent years, beside chemotherapy combination of differential factors cytokins and cytotoxic agents have been used in treatment of acute leukaemia particularly acute promyelocytic leukaemia. The present study was an evaluation of proliferation, cytotoxicity and differentiatio...
Previously we showed that granulocyte colony-stimulating factor (G-CSF) in vitro bioactivity is preserved when the protein is joined via a flexible 7 amino acid linker to an immunoglobulin-1 (IgG1)-Fc domain and that the G-CSF/IgG1-Fc fusion protein possessed a longer circulating half-life and improved hematopoietic properties compared to G-CSF in normal rats. We have extended this analysis by ...
CSF-1 and granulocyte/monocyte CSF (GM-CSF) were shown to modulate the levels of Ia gene and protein expression in bone marrow-derived macrophages (BMM). Recombinant GM-CSF induced high levels of Ia expression, similar to the levels induced by INF-gamma, while IL-3 had no effect. In contrast, recombinant CSF-1 not only suppressed the basal levels of Ia gene and protein expression in BMM, but al...
Researchers add serum to a classical medium at concentrations of 5 to 10% (v/v) to grow cellsin-vitro culture media. Unfortunately, serum is a poorly defined culture medium componentas its composition can vary considerably while serum-free cell culture media are an excellentalternative to standard serum-containing media and offer several major advantages. Advantagesof us...
سابقه : تمرین تناوبی شدید به عنوان یک روش تمرینی جدید از طریق مسیرهای مختلف می تواند موجب هایپرتروفی فیزیوژیک قلب می شود. از اینرو هدف از پژوهش حاضر تعیین اثر دو هفته تمرین تناوبی شدید بر G-CSF، گیرنده آن(G-CSFR) و C-Kit در بافت قلب موشهای صحرایی نر بود. مواد و روش ها: بر این اساس 10 سر موش 8 هفته ای نر با نژاد ویستار(با میانگین وزنی 7/8+75/234 گرم) در دو گروه کنترل و تمرین تقسیم شدند. گروه تمر...
abstract background: recently, stem cells have been used to facilitate healing in animal models of renal failure induced by acute ischemic and nephrotoxic damage. granulocyte colony-stimulating factor (g-csf) has been reported to stimulate stem cell mobilization from bone marrow and these cells may contribute to renal repair. objectives: in the present study, the effects of g-csf and stem cell ...
Head and neck squamous cell carcinoma (HNSCC) is marked by immunosuppression, a state in which the established tumor escapes immune attack. However, the impact of the premalignant and tumor microenvironments on immune reactivity has yet to be elucidated. The purpose of this study was to determine how soluble mediators from cells established from carcinogen-induced oral premalignant lesions and ...
Ootsuka Y, Blessing WW, Steiner AA, Romanovsky AA. Fever response to intravenous prostaglandin E2 is mediated by the brain but does not require afferent vagal signaling. Am J Physiol Regul Integr Comp Physiol 294: R1294–R1303, 2008. First published January 30, 2008; doi:10.1152/ajpregu.00709.2007.—PGE2 produced in the periphery triggers the early phase of the febrile response to infection and m...
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