An altered beta-tubulin gene that confers resistance to the fungicide benomyl was isolated from a genomic library of a UV-induced mutant of Cercospora kikuchii and used as a selectable marker for transformation. The level of benomyl resistance conferred to the transformants was at least 150-fold greater than the intrinsic resistance of the C. kikuchii recipient protoplasts. In the majority of c...

AIM To overcome fludioxonil resistance of Penicillium expansum, a mycotoxigenic fungal pathogen causing postharvest decay in apple, by using natural phenolic chemosensitizing agents. METHODS AND RESULTS Fludioxonil-resistant mutants of P. expansum were co-treated with different oxidising and natural phenolic agents. Resistance was overcome by natural phenolic chemosensitizing agents targeting...

Phenylamide-resistant isolates of Phytophthora infestans have gradually become an important part of populations in many countries. However, fungicide mixtures containing a phenylamide component are still an effective strategy for the control of late blight in potato and tomato. The proportion of phenylamide-resistant isolates fluctuates from year to year and within the season. Almost concurrent...

The fungal pathogen Sclerotinia sclerotiorum (Lib.) de Bary is worldwide in distribution and pathogenic to more than 400 plant species. This disease causes significant yield losses of various important crops including sunflower, canola, and soybean. Applying fungicides and crop rotation are currently the major methods of controlling this disease. However, fungicide chemicals are expensive, not ...

Phoma stem canker, caused by Leptosphaeria spp. is generally managed with demethylation inhibitor (DMI) fungicides in the Czech Republic. However, there have been reports of resistance to DMIs L. maculans populations. Fungicide management recommends application different modes action, either as mixtures or rotation other fungicide classes. The objective, therefore, was evaluate efficacy boscali...

Abstract Candidemia caused by Candida spp. is a serious threat in hospital settings being major cause of acquired infection and death possible contributor to Covid-19 mortality. incidence has been rising worldwide following increases fungicide-resistant pathogens highlighting the need for more effective antifungal agents with novel modes action. The membrane-bound enzyme alternative oxidase (AO...