The synthesis of bifunctional mesoporous silica nanoparticles is described. Two chemically orthogonal functionalities are incorporated into mesoporous silica by co-condensation of tetraethoxysilane with two orthogonally functionalized triethoxyalkylsilanes. Post-functionalization is achieved by orthogonal surface chemistry. A thiol-ene reaction, Cu-catalyzed 1,3-dipolar alkyne/azide cycloadditi...

un Qian rash Gharibi ailing He hejiang University oint Research Center of Photonics of the Royal Institute of Technology Sweden and hejiang University entre for Optical and Electromagnetic Research ijingang Campus, Hangzhou 310058 hina Abstract. Protoporphyrin IX PpIX -encapsulated mesoporous silica nanoparticles were synthesized, characterized, and utilized for photodynamic therapy PDT of canc...

A supramolecular assembly for visible light responsive release of cargo molecules is presented. Sulforhodamine 101 was loaded inside the mesopores of mercaptopropyl-functionalized mesoporous silica nanoparticles (MP-MSN) and entrapped by mercaptopropyl-coordinated Ru(bpy)(2)(PPh(3))-moieties. Irradiation with visible light triggers the release of capping species and loaded molecules.

Simultaneous improvement in CO2 permeability and CO2/N2 selectivity was obtained from mixed matrix membranes (MMMs) containing dual-functionalized mesoporous TiO2 hollow nanospheres (f-MTHS). Dual functionality resulted in the increased CO2 affinity and improved interfacial properties between inorganic nanofillers and the polymer matrix.

A mesoporous Zn-based metal-organic framework (MOF) was prepared from a shape-persistent phenylene ethynylene macrocycle functionalized with three -COOH groups. The rigid ligand has a ∼9 Å wide central cavity which serves as a predesigned pore. The macrocycles [π···π] stack into pairs, with their carboxylate groups connected via three Zn3O14C6H2 clusters. The resulting MOF has a void volume of ...

Tri-block copolymers (poly(ethylene oxide)–poly(propylene oxide)–poly(ethylene oxide), represented as EOxPOyEOx), pluronics (F127 = EO106PO70EO106, P65 = EO20PO30EO20, P85 = EO27PO39EO27, P103 = EO17PO55EO17, and P123 = EO20PO70EO20) and cationic surfactants (cethyltrimethylammonium bromide (CTAB)), two surfactant systems, form complex micelles that self-assemble into mesostructured particles w...

Highly ordered mesoporous Co3O4 materials have been prepared via a nanocasting route with three-dimensional KIT-6 and two-dimensional SBA-15 ordered mesoporous silicas as templates and Co(NO3)2 · 6H2O as precursor. Through changing the hydrothermal treating temperature of the silica template, ordered mesoporous Co3O4 materials with hierarchical structures have been developed. The larger pores a...

We present a novel therapeutic nanoplatform based on mesoporous silica nanoparticles encapsulating ferulic acid/gemcitabine and functionalized with anti-GPC1 antibodies to target human pancreatic cancer (PANC-1) cells.