give 50"h inhibition of binding ( lC5,,) was derived from these graphs. The values for ram proacrosin were as follows: unlabelled fucoidan ( 19.1 nM), dextran sulphate SO0 000 M, (3 1.6 nM), dextran sulphate 5000 M, (251 nM), polyvinylsulphate (326 nM), xylan (299 p ~ ) and mannan ( 1000 p ~ ) . The following solutions were tested. but did not reach 50%) inhibition at the concentrations given: ...

Carbohydrate-protein interactions are known to be important in gamete interactions. Several evidence indicated that a fucose-containing sulfated polysaccharide fucoidan was potential inhibitor of fertilization in vitro and thus fucose seemed to be part of the recognition signal of gamete interaction in mammals. In recent investigation we found that α-L-fucosidase activity was present in boar sp...

Fucoidan, a sulfated polysaccharide from the brown algae Fucus vesiculosus, has diverse biological properties, including anti-inflammatory, anticoagulant and antithrombotic activity. This study analyzed the therapeutic activity of total fucoidan (TF) from F. vesiculosus and that of purified fractions (F1 and F2) on zymosan-induced arthritis. Arthritis was induced by injecting zymosan into the k...

In the present study, two experiments were conducted to (1) evaluate the effect of laminarin and/or fucoidan on ileal morphology, nutrient transporter gene expression and coefficient of total tract apparent digestibility (CTTAD) of nutrients and (2) determine whether laminarin inclusion could be used as an alternative to ZnO supplementation in weaned pig diets. Expt 1 was designed as a 2 × 2 fa...

OBJECTIVES To evaluate potential hepatic metabolism-mediated drug interactions with fucoidan from Undaria pinnatifida (UPF) or Fucus vesiculosus (FVF) and potential growth inhibition activity with either fucoidan alone or with chemotherapy. In vivo studies were done to confirm safety and investigate fucoidan-mediated immune modulation. METHODS Cytochrome P450 (CYP450) 3A4, 2C8, 2C9, and 2D6 i...

A comparative study concerning the physicochemical, monomeric composition and biological characters among different fucoidan fractions is presented. Common purification techniques for fucoidan usually involve many steps. During these steps, the important structural features might be affected and consequently alter its biological activities. Three purified fractions were derived from Fucus vesic...

Abstract Fucoidan, a sulfated polysaccharide extracted from brown seaweed, has been proposed to effectively treat and prevent various viral infections. However, the mechanisms behind its antiviral activity are not completely understood. We investigate here global transcriptional changes in bone marrow-derived dendritic cells (BMDCs) using RNA-Seq technology. Through both analysis of differentia...

A fucoidan discovered in the plant Fucus vesiculosus, which lowered molecular weight of fucoidan, was ideal for its application pharmaceutical and food sectors. The aim to study impact ultrasound process parameters on weight, structure, antioxidant activity fucoidan. For optimization sonochemical such as temperature, sonication time, power (intensity), Box–Behnken design (BBD) through response ...

The interaction of proteins with polysaccharides represents a major and challenging topic in glycobiology, since such complexes mediate fundamental biological mechanisms. An affinity capillary electrophoresis method has been developed to evidence the complex formation and to determine the binding properties between an anticoagulant polysaccharide of marine origin, fucoidan, and a potential targ...