Focal segmental glomerulosclerosis (FSGS) is not an infrequent cause of nephrotic syndrome in the young. The incidence is 5-15%. Renal morbidity is significant and the disease relentlessly progresses to renal failure. Failure due to steroid unresponsiveness and resistance to cytotoxic drug regimen necessitates renal transplantation. However, recurrence of the primary disease (FSGS) in the allog...

Focal segmental glomerulosclerosis (FSGS) is a kidney histologic lesion that may be caused by multiple aetiologies and pathophysiological mechanisms, with podocyte injury depletion as the common denominator. FSGS subdivided into different subclasses: primary, secondary, genetic unknown forms. Notwithstanding overlapping clinical histological characteristics across forms of FSGS, their managemen...

The objective of this paper is to analyse the application of the Half-Sweep Gauss-Seidel (HSGS) method by using the Half-sweep approximation equation based on central difference (CD) and repeated trapezoidal (RT) formulas to solve linear fredholm integro-differential equations of first order. The formulation and implementation of the Full-Sweep Gauss-Seidel (FSGS) and HalfSweep Gauss-Seidel (HS...

Mutations in CD2-associated protein (CD2AP) have been identified in patients with focal segmental glomerulosclerosis (FSGS); however, reports of CD2AP mutations remain scarce. We performed Sanger sequencing in a patient with steroid-resistant FSGS and identified a heterozygous CD2AP mutation (p.T374A, c.1120 A . G). Our patient displayed mild cognitive decline, a phenotypic characteristic not p...

Focal segmental glomerulosclerosis (FSGS) can be classified as primary or secondary. Moreover, many causes of primary FSGS have been identified in recent years. In this regard, genetic circulating permeability factors and the abnormal podocyte expression of co-stimulatory molecules have been reported. However, the classification of this entity remains difficult to understand, mainly due to the ...

FSGS is a histological description of the glomerular pathological findings; Clinically it is characterised by proteinuria, usually of nephrotic range, hypoalbuminaemia and variable degrees of renal impairment [1]. Sever nephrotic syndrome may increase the risk of thromboembolism [2]. FSGS is classified according to the aetiology into primary (idiopathic) and secondary. Secondary FSGS may be due...

Mutations in CD2-associated protein (CD2AP) have been identified in patients with focal segmental glomerulosclerosis (FSGS); however, reports of CD2AP mutations remain scarce. We performed Sanger sequencing in a patient with steroid-resistant FSGS and identified a heterozygous CD2AP mutation (p.T374A, c.1120 A > G). Our patient displayed mild cognitive decline, a phenotypic characteristic not p...

Abstract We report a case of 38-year-old man who developed nephrotic syndrome shortly after the start Guselkumab for treatment plaque psoriasis. Renal biopsy showed focal segmental glomerulosclerosis (FSGS). The clinical course our is highly suspect drug induced FSGS since resolved cessation without relapse (2 years follow up). To best knowledge, this first describing lesions associated with us...

BACKGROUND Patients with focal segmental glomerulosclerosis (FSGS) are considered to have a poor prognosis and spontaneous remissions are seldom reported. However, FSGS is not a single disease entity. Our aim was to describe the clinical course in initially untreated patients with recently diagnosed idiopathic FSGS. METHODS This was a retrospective study of patients with a diagnosis of FSGS b...