OBJECTIVE To determine the data sources and 'look back' intervals to define comorbidities. DATA SOURCES Hospital discharge abstracts database (DAD), physician claims, population registry and death registry from April 1, 1994 to March 31, 2010 in Alberta, Canada. STUDY DESIGN Newly-diagnosed hypertension cases from 1997 to 2008 fiscal years were identified and followed up to 12 years. We def...

Repression of gene transcription is linked to regulation of chromatin structure through deacetylation of core histone amino-terminal tails. This action is mediated by histone deacetylases (HDACs) that function within active multiprotein complexes directed to the promoters of repressed genes. In vivo, HDAC3 forms a stable complex with the SMRT corepressor. The SMRT-HDAC3 complex exhibits histone...

INTRODUCTION Diffuse alveolar damage (DAD) is a morphological prototype of acute interstitial pneumonia. Hospital autopsies or open-lung biopsies are used to monitor common alveolar damage and hyaline membrane (HM) development histopathologically. The aim of this study was to detect histopathological profiles and frequency of DAD and HM in adult forensic autopsies. MATERIALS AND METHODS In to...

UNLABELLED Dento-alveolar disharmony (DAD) with crowding represents a predispose factor for periodontal pathology installing, especially when septic inflammation is associated. In this context, the identification of integrity or presence of the periodontal structure modifications becomes essential, any discovered element of periodontal pathology transforming into an important factor for a corre...

Analysis of rubber and rubberwood biomass management revealed an actualized twin-loop circularity arising from the multibillion-dollar export revenue downstream upstream segments. Despite resembling zero-waste resource-efficient system, natural exports does not translate as wealth smallholders, pressing them persistent ‘poor dad’ in value chain. This study dwells on how to empower smallholders ...

functions of the nervous system. He also furnishes us with the particulars of the experiments which he has recently made, with the view of elucidating some of the most difficult problems in physiology. He has moreover, in common with other physiological psychologists, had the presumption to suppose that the recent researches and conflicting experiments made both in this country and on the Conti...

high performance liquid chromatography coupled with photodiode array detector (hplc-dad) has been reported to quantify isolated flavonoids or these compounds in complex biological matrices, such as chinese herbal drugs and products from factories. this work was designed, therefore, to develop an hplc-dad system to separate quercetin, luteolin and apigenin and to quantify them in extractive solu...

DIAPH1 encodes human DIA1, a formin protein that elongates unbranched actin. The c.3634+1G>T DIAPH1 mutation causes autosomal dominant nonsyndromic sensorineural hearing loss, DFNA1, characterized by progressive deafness starting in childhood. The mutation occurs near the C-terminus of the diaphanous autoregulatory domain (DAD) of DIA1, which interacts with its N-terminal diaphanous inhibitory ...

Driving after drinking (DAD) is a serious public health concern found to be more common among college students than those of other age groups or same-aged non-college peers. The current study examined potential predictors of DAD among a dual-site sample of 3753 (65% female, 58% Caucasian) college students. Results showed that 19.1% of respondents had driven after 3 or more drinks and 8.6% had d...

Literature assumes that negation is more difficult to understand than affirmation, but this might depend on the pragmatic context. The goal of this paper is to show that pragmatic knowledge modulates the unfolding processing of negation due to the previous activation of the negated situation. To test this, we used the visual world paradigm. In this task, we presented affirmative (e.g., her dad ...