ardized herbal extract obtained from five different plants Thymus vulgaris (thyme), Glycyrrhiza glabra (licorice), Vitis vinifera (grape), Alpinia officinarum (lesser galangal), and Urtica dioica (stinging nettle) [1–3]. Here, we present the first case of successful ABS usage in the therapy of radiation colitis. A 71-year-old woman who had undergone pelvic radiotherapy due to cancer of the cerv...

Chlorzoxazone is a centrally acting muscle relaxant used to treat muscle spasm and the resulting pain and discomfort which are having shorter half life (1.1hour) with the dose administration of 3-4 times a day. The aim of the study was to prepare and evaluate the Chlorzoxazone sustained release tablets in order to reduce the dose frequency and to improve the patient compliance. The tablets were...

Purpose: To develop a pH-controlled two-pulse drug delivery system of amoxicillin in order to overcome the snag of biological tolerance and to improve bactericidal activity. Methods: The core tablets were compressed and coated with hydroxylpropyl methylcellulose (HPMC) of different viscosities with spray-dried lactose (SDL) as a pore former. The final two-pulse release tablet was prepared with ...

Ferula gummosa Boiss. (Apiaceae) is one of the natural plants of Iran. The whole plant, but especially the root, contains the gum resin "galbanum". A study of the comparative effects of galbanum gum and two standard binding agents--polyvinylpyrolidone and acacia--on characteristics of acetaminophen and calcium carbonate compacts was made. The Ferula gummosa gum was extracted and its swelling in...

Flexible fiberoptic bronchoscopy has been proven to be an effective tool for the assessment and characterization of airway inflammation. Visual inspection of airways affected by chronic bronchitis discloses an abnormal appearance characterized by erythema, edema, secretions, and friability. It was hypothesized that the visual appearance of airway inflammation could be assessed in a semiquantita...

The objective of the current study was to develop and optimize a sublingual tablet formulation of captopril which is an effective drug in the treatment of hypertension. Captopril containing tablets were prepared by direct compression method using different ingredients such as polyvinyl pyrrolidone, starch 1500, sodium starch glycolate and lactose (independent variables) and magnesium stearate, ...

The present study aims to formulate mouth dissolving tablets of montelukast sodium by direct compression method for the faster action, better absorption and improvement bioavailability drug in management Asthma. Total six formulations were developed with varying concentrations combination Crosspovidone Sodium starch glycolate as super disintegrating agents. prepared method. MDT evaluated variou...

sustained release oral delivery systems are designed to achieve therapeutically effective concentrations of drug in the systemic circulation over an extended period of time. the purpose of the present investigation was to design and evaluate sustained release matrix tablets of nifedipine, a poorly water soluble drug, employing hydroxypropyl methyl cellulose ( hpmc) and ethyl cellulose ( ec) as ...

The main components for tablet formulations are the fillers, binders, crushers, thinners and lubricants. Among these components, binders play a key role on powder cohesion properties during formation of granules. In this study, turmeric extract tablets were formulated using 15 g extract, 35 aerosil, 12.8 lactose, 1% magnesium stearate, 200 ml aquadest gelatin as binder. To evaluate effect formu...

objective(s):the aim of this study was to improve flowability and compressibility characteristics of starch to use as a suitable excipient in direct compression tabletting. quasi-emulsion solvent diffusion was used as a crystal modification method. materials and methods: corn starch was dissolved in hydrochloric acid at 80˚c and then ethanol as a non-solvent was added with lowering temperature ...