نتایج جستجو برای: free iron

تعداد نتایج: 649758  

Journal: :American journal of physiology. Gastrointestinal and liver physiology 2002
Jennifer R Follett Yasushi A Suzuki Bo Lönnerdal

Heme-Fe is an important source of dietary iron in humans. Caco-2 cells have been used extensively to study human iron absorption with an emphasis on factors affecting nonheme iron absorption. Therefore, we examined several factors known to affect heme iron absorption. Cells grown in bicameral chambers were incubated with high specific activity [59Fe]heme alone or with 1% globin, BSA, or fatty a...

Journal: :Circulation 2002
Andrei L Kleschyov Maria Wendt Thomas Munzel

Role of Nonheme Iron–Nitric Oxide Complexes To the Editor: In a recent paper, Tulis and coworkers1 reported that transfectional overexpression of heme oxygenase-1 (HO-1) inhibits arterial remodeling after balloon angioplasty via a mechanism involving apoptosis. HO-1 is a stress response protein that degrades heme to carbon monoxide, biliverdin, and nonheme iron. In general, overexpression of HO...

Journal: :The Journal of pharmacology and experimental therapeutics 2000
S Y Chen K K Sulik

Previous studies using cell and whole embryo cultures have shown that free radicals play an important role in the ethanol-induced death of mouse neural crest cells (NCCs; a significant cell type with respect to the genesis of alcohol-related birth defects). This investigation was spurred by reports of increased iron in ethanol-exposed fetuses and the knowledge that iron can initiate the product...

Journal: :The Journal of clinical investigation 1989
J R Mahoney P E Hallaway B E Hedlund J W Eaton

Acute iron intoxication is a frequent, sometimes life-threatening, form of poisoning. Present therapy, in severe cases, includes oral and intravenous administration of the potent iron chelator, deferoxamine. Unfortunately, high dose intravenous deferoxamine causes acute hypotension additive with that engendered by the iron poisoning itself. To obviate this problem, we have covalently attached d...

Journal: :The American journal of clinical nutrition 2006
Bo Lönnerdal Annika Bryant Xiaofeng Liu Elizabeth C Theil

BACKGROUND Dietary ferritin, a protein cage around an iron mineral, is an underestimated source of bioavailable iron. Plant ferritin, the most common dietary ferritin, has not been studied. Iron from animal ferritin is absorbed as well as is iron from FeSO4 in women. OBJECTIVE The objective was to examine iron absorption from purified soybean ferritin. DESIGN Healthy, nonanemic women (n = 1...

Journal: :Chemical communications 2009
Wei Han Armin R Ofial

Iron(ii) and iron(iii) salts catalyze the oxidative alpha-cyanation of tertiary amines by trimethylsilyl cyanide in the presence of tert-butylhydroperoxide under acid-free conditions at room temperature.

Background:Vibrio splendidusVs is an important aquaculture pathogen that can infect a broad host of marine organisms. In our previous study, an antagonistic bacterium Vibrio sp. V33 that possessed inhibitory effects on the growth and virulence of a pathogenic isolate V.splendidusVs was identified. O...

Journal: :Asian Pacific journal of tropical biomedicine 2014
Kanokwan Kulprachakarn Nittaya Chansiw Kanjana Pangjit Chada Phisalaphong Suthat Fucharoen Robert C Hider Sineenart Santitherakul Somdet Srichairatanakool

OBJECTIVE To evaluate the iron-chelating properties and free-radical scavenging activities of 1-(N-acetyl-6-aminohexyl)-3-hydroxy-2-methylpyridin-4-one (CM1) treatment in chronic iron-loaded β-thalassemic (BKO) mice. METHODS The BKO mice were fed with a ferrocene-rich diet and were orally administered with CM1 [50 mg/(kg.day)] for 6 months. Blood levels of non-transferrin bound iron, labile p...

2013
Rahul G. Sangani Andrew J. Ghio

Iron is an essential nutrient utilized in almost every aspect of cell function and its availability has previously limited life. Those same properties which allow iron to function as a catalyst in the reactions of life also present a threat via generation of oxygen-based free radicals. Accordingly; life exists at the interface of iron-deficiency and iron-sufficiency. We propose that: (1) human ...

Journal: :Clinical journal of the American Society of Nephrology : CJASN 2011
Sudhir V Shah Mohan M Rajapurkar Radhakrishna Baliga

What is Catalytic (Labile) Iron, and Why is it Important? The pathologic effects of iron accumulation in tissue in iron-overload states, such as are described in patients with thalassemia, are widely known. What is new in the field is the recognition that iron plays an important role in the pathophysiology of tissue injury in the absence of systemic iron overload. Critical to iron’s importance ...

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