BACKGROUND Data on early determinants of outcome in infective endocarditis (IE) are limited. We evaluated the prognostic significance of early clinical characteristics in a large, prospective cohort of patients with IE. METHODS AND RESULTS Two hundred sixty-seven consecutive patients with definite or possible IE by modified Duke criteria and echocardiography performed within 7 days of present...

Metabolic syndrome (MS) is a rising disease entity characterized by a clustering of metabolic conditions. Although prevalence of obesity as defined by the World Health Organization (WHO) is relatively low in Asia compared to western countries, metabolic syndrome is growing into a significant public health problem. Comparative studies indicate that metabolic responses to obesity may be greater i...

The effect of sex on the etiology, risk factors, comorbidities, treatment and prognosis in patients with heart failure (HF) encountered in routine clinical practice in Asian populations has not been well described. The objective of the present study was to elucidate sex differences with respect to the clinical characteristics, treatment, and prognosis of HF patients treated in routine clinical ...

Fifty years of research at the Framingham Heart Study have made important contributions to the diagnosis and treatment of cardiovascular disease (CVD). Within the scope of this prospective population-based cohort study, research investigations from the Framingham Nutrition Studies have developed and advanced nutritional epidemiologic methods, many of which are highlighted here. Ongoing nutritio...

T he concept of a “metabolic syndrome ” conferring increased risk of incident type 2 diabetes and cardiovascular disease (CVD) has been around for more than a couple of decades. Recent publication of clinical definitions has transformed the metabolic syndrome from a physiological curiosity to a major focus of research and of clinical and public health interest (1,2). The metabolic syndrome is g...

Dhanjoo N. Ghista1, Liang Zhong2, Leok Poh Chua3, Ghassan S. Kassab4, Yi Su5 and Ru San Tan2 1Department of Graduate and Continuing Education, Framingham State University, Framingham, Massachusetts, 2Department of Cardiology, National Heart Centre, 3School of Mechanical and Aerospace Engineering, Nanyang Technological University, 4Departments of Biomedical Engineering, Surgery, Cellular and Int...

1 Brigham and Women’s Hospital, Division of Endocrinology, Diabetes and Hypertension, Boston, MA; 2 Boston University, Department of Mathematics, Boston, MA; 3 Massachusetts General Hospital, Division of Radiology, Boston, MA; 4 Federal Foundation School of Medical Sciences of Porto Alegre, Porto Alegre, Rio Grande de Sul, Brazil; 5 NHLBI’s Framingham Heart Study, Framingham, MA; 6 Massachusett...

OBJECTIVE To compare the predicted risk of coronary heart disease (CHD) and incident myocardial infarction (MI) using Framingham score equations with the observed rate of MI in Mexican subjects. MATERIAL AND METHODS Longitudinal study that included 1 667 men and women aged 35 to 64 years without MI at baseline. Incident MI was defined by electrocardiogram or death certificate. The predicted r...

OBJECTIVE Our aim was to compare 2 Framingham vascular risk scores with a dementia risk score in relation to 10-year cognitive decline in late middle age. METHODS Participants were men and women with mean age of 55.6 years at baseline, from the Whitehall II study, a longitudinal British cohort study. We compared the Framingham general cardiovascular disease risk score and the Framingham strok...

We designed this study to explore to what extent the excess risk of cardiovascular events in diabetic individuals is attributable to hypertension. We retrospectively analyzed prospectively collected data from the Framingham original and offspring cohorts. Of the 1145 Framingham subjects newly diagnosed with diabetes mellitus who did not have a previous history of cardiovascular events, 663 (58%...