Background Understanding and addressing the needs of frail patients has been identified as an important strategy by the Nova Scotia Health Authority (NSHA). Primary care (PC) providers are in a key position to aid in the identification of, and response to frailty as part of routine care. Unlike singular chronic conditions such as diabetes and hypertension which garner a disease-based appr...

The management of hypertension in frail older adults remains controversial, as these patients are underrepresented clinical trials and practice guidelines. Overtreatment may cause harm while undertreatment lead to greater risk cardiovascular events. Our research aims examine this controversy provide guidance regarding deprescribing decisions adults. Current evidence suggests that there be minim...

Abstract Background and Aims Chronic Kidney Disease (CKD) patients with frailty have been shown to a shorter survival time compared non-frail individuals. Additionally, has linked earlier initiation of dialysis among CKD patients. Despite the availability over 50 assessment tools in literature, few applied studies older adults CKD. There is need for comprehensive analysis different identify mos...

Background: Chronic low-grade inflammation may be a cardinal pathophysiologic feature in the pathogenesis of frailty. Interferon-gamma (INF-γ) is an understudied proinflammatory cytokine in frailty that induces many inflammatory pathways including the guanosine triphosphate cyclohydrolase 1 (GTP-CH1) pathway. Our aim was to evaluate the GTP-CH1 pathway in Egyptian frail elderly subjects. ...