Cracked and un-cracked Brazilian disc specimens subjected to diametral compression were used for conducting fracture toughness and tensile strength experiments on a polymer concrete (PC) material. The value of mode I fracture toughness (KIc) was determined from the center- cracked Brazilian disc and the indirect tensile strength (σt) was obtained from the un-cracked Brazilian disc specimen. The...

cracked and un-cracked brazilian disc specimens subjected to diametral compression were used for conducting fracture toughness and tensile strength experiments on a polymer concrete (pc) material. the value of mode i fracture toughness (kic) was determined from the center- cracked brazilian disc and the indirect tensile strength (σt) was obtained from the un-cracked brazilian disc specimen. the...

©2006 British Editorial Society of Bone and Joint Surgery doi:10.1302/0301-620X.88B6. 17524 $2.00 J Bone Joint Surg [Br] 2006;88-B:701-5. In vivo studies have shown that bone morphogenetic proteins (BMPs), transforming growth factor (TGF) beta, insulin-like growth factor (IGF), fibroblast growth factor (FGF), plateletderived growth factor (PDGF) and vascular endothelial growth factor (VEGF) are...

There is evidence to suggest that fractures heal more rapidly in patients with a head injury as a result of systemic factors released from the site of this injury. We have measured the circulating level of insulin-like growth factor-1 (IGF-1) and IGF binding protein-3 (IGFBP-3) in serum because of their known involvement in the stimulation of the activity of osteoblasts and the healing of fract...

Crack fronts play a fundamental role in engineering models for fracture: they are the location of both crack growth and the energy dissipation due to growth. However, there has not been a rigorous mathematical definition of crack front, nor rigorous mathematical analysis predicting fracture paths using these fronts as the location of growth and dissipation. Here, we give a natural weak definiti...

For crack growth along an interface between dissimilar materials the effect of combined modes I, II and III at the cracktip is investigated. First, in order to highlight situations where crack growth is affected by a mode III contribution, examples of material configurations are discussed where mode III has an effect. Subsequently, the focus is on crack growth along an interface between an elas...

background at altnagelvin, a district general hospital in northern ireland, we have observed that a significant number of hip fracture admissions are later readmitted for treatment of other medical conditions. these readmissions place increasing stress on the already significant burden that orthopedic trauma poses on national health services. objectives the aim of this study was to review a ser...

This study investigated the localization of critical enzymes involved in arachidonic acid metabolism during the initial and regenerative phases of mouse femur fracture healing. Previous studies found that loss of cyclooxygenase-2 activity impairs fracture healing while loss of 5-lipoxygenase activity accelerates healing. These diametric results show that arachidonic acid metabolism has an essen...

Bisphosphonates alleviate bone pain and fractures associated with osteogenesis imperfecta (OI). Using the oim mouse model to simulate variations in OI severity, the effect of pamidronate on bone growth was assessed. Homozygous (oim/oim) and heterozygous (oim/wt) mice from 4 to 12 weeks of age were given pamidronate at 0 mg/kg/wk (control), 1.25 mg/kg/wk (low) and 2.5 mg/kg/wk (high). Humerus an...