Methoxysubstituted 5,6-dihydro-indolo[2,l-a]isoquinolines with a methyl (2b-f) or a formyl group at C-12 (4a-f) and 12,12-dimethylisoquinolinium salts (3b-f) were synthesized and tested for cytostatic activity in vitro. The tetramethoxy-indoloisoquinoline 4f was the most active derivative in the P 388 Dl leukemia cell line, whereas compounds with two methoxy groups (4a, 4b) were more potent aga...

Eleven derivatives of 7,12-dimethylbenz(a)anthracene were tested for carcinogenicity in Sprague-Dawley female rats by the s.c. injection of 1.0 or 0.1 mg of compound dissolved in 0.1 ml of sesame oil on alternate days for 20 doses. Eight derivatives [7-hydroxymethyl-12-methyl-, 7-formyl-l 2-methyl-, 7-methoxymethyl-l 2-methyl-, 7-acetoxymethyl-l 2-methyl-, 7-benzoyloxymethyl-l 2-methyl-. 7-iodo...

The tumorigenic activities of benzo(e)pyrene, 9,10-dihydrobenzo(e)pyrene, 9,10-epoxy-9,10,11,12-tetrahydrobenzo(e)-pyrene, the diastereomeric bay-region 9,10-dihydroxy-11,12-epoxy-9,10,11,12-tetrahydrobenzo(e)pyrenes, and the K-region benzo(e)pyrene 4,5-oxide were assessed in newborn mice, Swiss-Webster mice received a total dose of 0.7 mumol of compound divided into three i.p. injections of 0....

A microbial consortium which rapidly mineralized the environmentally persistent pollutant benzo[a]pyrene was recovered from soil. The consortium cometabolically converted [7-(14)C]benzo[a]pyrene to (14)CO(2) when it was grown on diesel fuel, and the extent of benzo[a]pyrene mineralization was dependent on both diesel fuel and benzo[a]pyrene concentrations. Addition of diesel fuel at concentrati...

Sixteen lipophilic N-(X)sulfonyl carbamoyl lariat ethers with polyether ring sizes of 12-crown-4, 14-crown-4, 15-crown-5, and 18-crown-6 are utilized for competitive alkali metal cation extractions from aqueous solutions into chloroform. Variation of the electron-withdrawing properties of X in the series of methyl, phenyl, 4-nitrophenyl, and trifluoromethyl allows the influence of the acidity o...