Purpose: Diltiazem, a calcium ion cellular influx inhibitor is known for its limited and variable bioavailability. This study is intended to explore the benefits of microemulsion formulation as oral drug delivery system for immediate release to improve the bioavailability and efficacy of Diltiazem. Methods: Oil in water microemulsion was prepared using the simple water titration method. The opt...

The effect of geometrical parameters involved in vortex extrusion (VE) die design, on AA1050 aluminium alloy processed by VE were investigated using finite element analysis (FEA) and response surface methodology (RSM). For this, VE die length (L), reduction in area (RA), twist angle , and position of control points in Beziers' formulation (C1) were considered as input parameters and strain inho...

We develop a covariance-matrix-based uncertainty analysis for vector-network-analyzer scattering-parameter measurements. The covariance matrix captures all of the measurement uncertainties and statistical correlations between them. This allows the uncertainties of vector-network-analyzer scattering-parameter measurements to be propagated into the uncertainties of other quantities derived from s...

structural dynamic parameters: natural period, shape modes and damping ratio of vibration, play a decisive role on the seismic behavior of those structures. there are several methods for determining of the structural dynamic parameters, such as: free vibration, ambient vibration and force vibration tests. in this research the structural response of a three-story building (the natural frequencie...

Present research was an attempt to develop a statistical relationship between physicochemical properties of polymers and physical characteristics of fast disintegrating tablets of ibuprofen. Polymers are generally used in formulation to provide effective drug delivery give as well as good physical appearance. Here, several physicochemical properties of three different polymers were calculated a...

Principal component analysis (PCA) for binary data, known as logistic PCA, has become a popular alternative to dimensionality reduction of binary data. It is motivated as an extension of ordinary PCA by means of a matrix factorization, akin to the singular value decomposition, that maximizes the Bernoulli log-likelihood. We propose a new formulation of logistic PCA which extends Pearson’s formu...

An efficient measurement methodology is proposed to construct the scattering parameters of a multi-port device using a four-port vector network analyzer (VNA) without the external un-terminated ports. By using the four-port VNA, the reflected waves from the un-terminated ports could be minimized. The proposed method significantly enhances the accuracy of the S-parameters with less number of mea...