Biological encapsulation and the foreign body reaction can impair the performance of implanted drug release devices. In this article, the classic definition of biocompatibility is questioned. Examples are presented of biomaterials showing unique healing behavior. A new paradigm for biomaterials healing is proposed in which non-specific protein adsorption is inhibited and matricellular proteins ...

Serum was ultrafiltered by centrifugation through size-selective membranes, and the ultrafiltrates were analyzed directly for glucose, urea nitrogen, creatmine, and uric acid. The concentrations obtained were equivalent to their concentration in conventional protein-free filtrates. This procedure eliminates the need for specific precipitating methods required in various analyses, and yields und...

The core shell of hepatitis B virus is a potent immune stimulator, giving a strong neutralizing immune response to foreign epitopes inserted at the immunodominant region, located at the tips of spikes on the exterior of the shell. Here, we analyze structures of core shells with a model epitope inserted at two alternative positions in the immunodominant region. Recombinantly expressed core prote...

Introduction Heat shock proteins (Hsps) are among the most highly conserved protein families in all forms of life. Although referred to as heat shock proteins, most of these proteins are expressed at significant levels all cells under normal growths conditions and are essential for cellular growth at all physiologically relevant temperatures. Heat shock proteins perform important functions in t...

The use of Lactococcus lactis to deliver a chosen antigen to the mucosal surface has been shown to elicit an immune response in mice and is a possible method of vaccination in humans. The recent discovery on Gram-positive bacteria of pili that are covalently attached to the bacterial surface and the elucidation of the residues linking the major and minor subunits of such pili suggests that the ...

Photosynthetic Cyanobacteria can be used as a chassis for different synthetic biology approaches. However, quantitative comparison of tools engineering, such those heterologous gene expression, is often not available. Here, we report the comparative quantification protein production in Synechococcussp.PCC 7002 regarding expression cassettes and locations foreign integration using sf-GFP reporte...