In Vitro Maturation (IVM) is a method that immature oocytes in antral follicles are extracted and matured in laboratry conditions. This review has attempted to provide the current knowledge and recent findings in in vitro maturation of oocytes and highlights the most important factors involved in this process. The review is based on literature reports and the author's experience. In IVM cycles,...

Intrinsic Notch signaling in intestinal epithelial cells restricts secretory cell differentiation. In gut-associated lymphoid tissue (GALT), stromal cells located beneath the follicle-associated epithelium (FAE) abundantly express the Notch ligand delta-like 1 (Dll1). Here, we show that mice lacking Rbpj-a gene encoding a transcription factor implicated in Notch signaling-in intestinal epitheli...

introduction: melatonin acts as an indirect antioxidant and is a powerful direct free radical scavenger and direct responses to melatonin in the gonads are detected. this study aims to investigate the influence of different doses of melatonin on preantral follicle development and oogenesis of in vitro cultured mouse ovarian follicles. materials and methods: preantral follicles with diameters of...

Sexual maturation of post-smolts is a concern for Atlantic salmon producers, and its occurrence dependent upon factors such as water temperature energy availability, among others. The present study was designed to investigate the effect different temperatures feeding regimes on testis development local regulation spermatogenesis in post-smolts. A 3 × 2 factorial design used, with three (8 °C, 1...

Cisplatin is a first-line chemotherapeutic agent for ovarian cancer that acts by promoting DNA cross links and adduct. However drug resistance and considerable side effects including reproductive toxicity remain a significant challenge. PTEN is well known as a tumor suppressor function which plays a fundamental role in the regulation of the cell cycle, apoptosis and development of cancer. At th...

We have previously shown that fatty acid oxidation (FAO) is required for AMP-activated protein kinase (PRKA)-induced maturation in vitro. In the present study, we have further investigated the role of this metabolic pathway in hormone-induced meiotic maturation. Incorporating an assay with (3)H-palmitic acid as the substrate, we first examined the effect of PRKA activators on FAO levels. There ...

Mycotoxin zearalenone is a phytoestrogenic substance that can disrupt the functioning of organs reproductive system cows. At same time, hyperestrogenic state occurs, which
 leads to overeating, multiple unsuccessful inseminations and infertility cows.
 The purpose research investigate effect single application drugs based on aromatase inhibitors main biochemical hormonal parameters bl...

The ultrastructural analysis of oocytes and ovarian follicles has been used to evaluate the effects of assisted reproductive techniques, such as cryopreservation or in vitro oocyte maturation. It also benefits the understanding of such complex mechanisms that occur during folliculogenesis. From the beginning of primordial follicles growth until oocyte maturation in preovulatory follicles oocyte...

Chalcalburnus mossulensis from the cyprinidae family is one of the indigenous fish in Gheshlagh Lake of Kordestan, Iran. Ligula intestinalis is one of the infective parasites among various species of fish and causes gonads atrophy. In this study, after detection of species and age of samples, the effects of this parasite on gonads tissues and sexual maturation of Chalcalburnus mossulensis were ...

STUDY QUESTION What are the direct effects of androgens on primate follicular development and function at specific stages of folliculogenesis? SUMMARY ANSWER Androgen addition altered primate follicle survival, growth, steroid and anti-Müllerian hormone (AMH) production, and oocyte quality in vitro, in a dose- and stage-dependent manner. WHAT IS KNOWN ALREADY Androgens have local actions in...