OBJECTIVES Co-prescription of folic acid in patients receiving low dose oral methotrexate is recommended because it reduces adverse events and prolongs the use of methotrexate (MTX). However, little is known about how often new users of methotrexate are co-prescribed folic acid, and what factors are associated with its use. We aimed to determine the prevalence, predictors of, and persistence of...

Countries worldwide, including the Netherlands, recommend that women planning pregnancy use a folic acid supplement during the periconception period. Some countries even fortify staple foods with folic acid. These recommendations mainly focus on the prevention of neural tube defects, despite increasing evidence that folic acid may also influence birth weight. We examined whether periconception ...

Targeted drug delivery system is an effective method for the diagnosis and treatment of cancer, it has received much attention because its low side effects therapeutic efficacy. Folic acid receptor highly expressed on surface most cancer cells, but or not normal ligand folate a high affinity. attached to carriers can be targeted cells. This paper introduces folic receptors, briefly describes me...

Hematological changes and serum iron, vitamin B12 and folate levels after administration of iron plus folic acid were com· pared with changes and levels after supplement of iron alone in 100 pregnant women. No hematological benefits by adding folic acid was revealed. It is concluded that folic acid deficiency in pregnant women is mild and routine supplementation of folic acid is not necessary e...

Many instances of a close relationship between folic acid and ascorbic acid have been reported in the literature. Johnson and Dana (1) have shown that ascorbic acid relieves many of the abnormalities noted in a folic acid deficiency syndrome. Woodruff and Darby (2) have reported that folic acid aids in correcting the abnormal tyrosine metabolism of the scorbutic guinea pig. Nichol and Welch (3,...

Many instances of a close relationship between folic acid and ascorbic acid have been reported in the literature. Johnson and Dana (1) have shown that ascorbic acid relieves many of the abnormalities noted in a folic acid deficiency syndrome. Woodruff and Darby (2) have reported that folic acid aids in correcting the abnormal tyrosine metabolism of the scorbutic guinea pig. Nichol and Welch (3,...

This study was conducted as an initial investigation of in vivo folate kinetics in healthy men (n = 4) and made use of a chronic-administration protocol with stable-isotope labeling. Subjects were given 0.453 mumol (200 micrograms) total folic acid in aqueous solution daily throughout the 18-wk study while they consumed self-selected folate-adequate diets. After a 2-wk pretrial period with unla...