نتایج جستجو برای: folate targeting
تعداد نتایج: 159458 فیلتر نتایج به سال:
Sir, Periconceptional supplementation with extra folic acid,1 or a multivitamin preparation containing folic acid2,3 reduces the recurrence and occurrence rate of neural tube defect (NTD). Also, the Department of Health’s expert Advisory group recommends that all women should take an extra 0.4 mg folic acid before conception and during the early months of pregnancy. Between September 1994 and M...
Folate receptors (FR) may be of use for targeted delivery of cytotoxic drugs in invasive urothelial carcinoma (iUC), for which improved therapy is needed. FR expression and function in iUC were explored and the antitumor activity and toxicity of a folate-targeted vinblastine conjugate were evaluated in dogs with naturally occurring iUC, an excellent model for human iUC. FR immunohistochemistry ...
The development of specialized nanoparticles for use in the detection and treatment of cancer is increasing. Methods are being proposed and tested that could target treatments more directly to cancer cells, which could lead to higher efficacy and reduced toxicity, possibly even eliminating the adverse effects of damage to the immune system and the loss of quick replicating cells. In this mini-r...
the present study , was an attempt to develop galactosylated albumin nanoparticles of simvastatin for treatment of hypercholesterolemia. by developing the galactosylated nanoparticulated delivery the required action of drug at the target site at liver can be provided. the advantage of targeting helps to reduce the systemic side effects which may be occur due to the distribution of the drug to t...
background: several studies showed that elevated plasma homocysteine level is a risk factor for coronary artery disease (cad). a common polymorphism c677t of methylenetetrahydrofolate reductase (mthfr) gene is reported to be associated with decreased enzyme activity and increased blood homocysteine level. methods: this study evaluated the association between c677t polymorphism and blood homocys...
Theranostics is emerging as a popular strategy for cancer therapy; thanks to the development of nanotechnology. In this work, we have combined an HSV-TK/GCV suicide gene system and near-infrared quantum dots, as the former is quite effective in liver cancer treatment and the latter facilitates tumor imaging. A folate-modified theranostic liposome (FL/QD-TK) was developed, which is composed of a...
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