BACKGROUND Rodent studies show that neurogenesis is necessary for mediating the salutary effects of antidepressants. Nonhuman primate (NHP) studies may bridge important rodent findings to the clinical realm since NHP-depression shares significant homology with human depression and kinetics of primate neurogenesis differ from those in rodents. After demonstrating that antidepressants can stimula...

BACKGROUND Women are at great risk for mood and anxiety disorders during their childbearing years and may become pregnant while taking antidepressant drugs. In the treatment of depression and anxiety disorders, selective serotonin reuptake inhibitors (SSRIs) are the most frequently prescribed drugs, while it is largely unknown whether this medication affects the development of the central nervo...

introduction: depression is one of the most frequent psychiatric disorders in the world with occurs with higher incidence in women. in the present study, the effect of water-alcoholic extract of papaver rhoeas l. on forced swimming test (fst) in swiss-webster mice were examined. methods: we used swiss-webster mice (20-25 g) to execute fst on them. the plant extract (1, 10, 30, and 100 mg/kg) wa...

background: this study compares the efficacy of fluoxetine (serotonin-selective reuptake inhibitors-ssri) with doxepin (tricyclic antidepressants –tcas- antihistaminic) in treatment of irritable bowel syndrome (ibs). methods: this randomized clinical trail recruited 200 patients who had referred to kermanshah imam reza hospital during the period 2006-7. all the patients had been diagnosed with ...

Fluoxetine is an antidepressant widely used to treat depressive and anxiety states. Due its mode of action in the central nervous system (selective serotonin reuptake inhibitor (SSRI)), it becomes toxic non-target organisms, leading changes that are harmful their survival. In this work, effects fluoxetine on juvenile zebrafish (Danio rerio) were evaluated, assessing biochemical (phase II biotra...

Recent detection of fluoxetine in the aquatic environment and fish suggests a possibly high accumulation of fluoxetine; however, no report is available on the bioaccumulation of fluoxetine in aquatic organisms. Since bioaccumulation of fluoxetine was probably dependent on pH near the pK(a) value of 10.1, experiments were conducted approximately at pH 7, 8, and 9. Distribution coefficients betwe...

Fluoxetine [+/--N-methyl-3-phenyl-3-[(alpha, alpha, (-trifluoro-p-tolyl)oxy]-propylamine)] a selective serotonin reuptake inhibitor, is widely used in treating depression and other serotonin-dependent disease conditions. Racemic, (R)- and (S)-fluoxetine are potent reversible inhibitors of CYP2D6, and the racemate has been shown to be a mechanism-based inhibitor of CYP3A4. Racemic fluoxetine als...

Fluoxetine, commonly known as Prozac, is the first representative of the so-called new generation of antidepressants that promise efficacy, with few side effects, against deep depression, nervous bulimia, and anxiety. As there is a growing number of people suffering from anxiety and depression; consequently, the use of fluoxetine is also increasing. Verifying absence of drug effects such as cyt...

OBJECTIVE To identify neuropsychological predictors of treatment response to cognitive-behavioral therapy (CBT) and fluoxetine in treatment-naïve adults with obsessive-compulsive disorder (OCD). METHOD Thirty-eight adult outpatients with OCD underwent neuropsychological assessment, including tasks of intellectual function, executive functioning and visual and verbal memory, before randomizati...

In the present study, we investigated the effects induced by fluoxetine treatment (10 mg/kg) for either 1 or 21 consecutive days on arterial pressure and heart rate basal levels, baroreflex activity, hemodynamic responses to vasoactive agents and cardiovascular responses to acute restraint stress. Mild hypertension was observed after 21 days of treatment, but not after administration for 1 day....