BACKGROUND The long-term effects of opiate use on human brain are not known. The goal of this preliminary study was to determine whether human subjects with histories of opiate dependence have persistent differences in brain function as compared with individuals without substance use disorders, and whether methadone maintenance reverses or ameliorates the potential abnormality. METHOD Positro...

BACKGROUND For a number of years, FDG-PET was considered as a gold standard for the differential diagnosis of recurrent glioma and radionecrosis. Recently published papers have introduced a wealth of scepticism into this area. The aim of this work is to specify the added value of FDG PET, as compared to MRI, in terms of diagnostics of recurrent gliomas in the clinical setting of the PET Centre ...

Despite the excellent clinical performance of fluorodeoxyglucose (FDG) as a cancer-imaging agent for positron emission tomography (PET), false positive and false negative results can be problematic in some clinical settings. Radiopharmaceutical development has recently focussed on the search for new PET tracers that could complement or replace FDG in such settings. Due to the general availabili...

This study compared brain glucose metabolism during sevoflurane anaesthesia and propofol anaesthesia using positron emission tomography (PET) in the same eight human volunteers. All the volunteers were anaesthetized twice, with a 1-week interval. Half of the volunteers received sevoflurane on the first occasion and propofol on the second; the other half received the two anaesthetics in the reve...

We agree with Roh et al.1 that cancerous and pre-cancerous lesions may be harboured by the finding of incidental F18-fluorodeoxyglucose (FDG) uptake on positron emission tomography (PET) scan. This study-and our own data2-advocates for urgent investigation of such findings, especially considering the treatment implications for patients undergoing therapy for other established malignancies (whic...

BACKGROUND We compared PET/MRI with PET/CT in terms of lesion detection and quantitative measurement to verify the feasibility of the novel integrated imaging modality for oncological applications. METHODOLOGY/PRINCIPAL FINDINGS In total, 285 patients referred to our PET/CT center for oncological indications voluntarily participated in this same-day PET/CT and PET/MRI comparative study. PET/C...

Purpose This work aimed at describing the time course of vitreous clearance through the use of positron emission tomography (PET) as a noninvasive tool for pharmacokinetic studies of intravitreal injection. Methods The pharmacokinetic profile of intravitreal injections of molecules labeled with 18Fluorine (18F) was evaluated in adult Sprague Dawley rats by using a dedicated small-animal PET/c...

Graft infections after aortic replacement are a rare, but severe complication. Because surgical removal of the infection source is essential, an accurate diagnosis is required to prevent unnecessary treatment. Both of the patients described herein were diagnosed with graft infections using dual-modality positron emission tomography-computed tomography; one patient was a false-positive, and the ...

UNLABELLED We addressed the questions of how cerebral glucose transport and phosphorylation change under acute hypoglycemia and what the underlying mechanisms of adaptation are. METHODS Quantitative (18)F-FDG PET combined with the acquisition of real-time arterial input function was performed on mice. Hypoglycemia was induced and maintained by insulin infusion. PET data were analyzed with the...

Assessing the response to treatment as soon after treatment initiation is one of the key reasons for imaging lymphoma patients. The optimal time after initiating treatment for assessing response to treatment has yet to be determined. Therefore, we were prompted to review our experience with serial (18)F-FDG PET/CT in patients undergoing treatment for Hodgkin's disease (HD) and non Hodgkin's lym...