New series of hydrazones 5-18 were synthesized, in good yields, by reacting 4-methyl-2-(4-(trifluoromethyl)phenyl)thiazole-5-carbohydrazide with differently substituted benzaldehyde. The resulting compounds were characterized via elemental analysis, physico-chemical and spectral data. An antimicrobial screening was done, using Gram (+), Gram (-) bacteria and one fungal strain. Tested molecules ...

A mild and efficient nickel-catalyzed reductive cross-coupling between fluorinated secondary alkyl bromides and (hetero)aryl iodides is described. The use of FeBr2 as an additive successfully overcomes the hydrodebromination and β-fluorine elimination of fluorinated substrates and allows the efficient synthesis of a wide range of trifluoromethyl and difluoroalkyl containing aliphatic compounds ...

In order to evaluate the influence of substitution on biological properties of Schiff bases and their metal complexes, a series of differently substituted fluorine-containing Schiff bases starting from the drug isoniazid (isonicotinylhydrazide) were prepared and their structures were established by single-crystal X-ray diffraction. Also, four copper(II) complexes of these Schiff bases were synt...

Strontium (Sr) substituted calcium phosphate (CaP) coatings have stimulated a lot of interest as Sr is known to provide osteoconductive properties. Most the work date with respect has focused on creation crystalline Sr-substituted hydroxyapatite (HA), opposed amorphous coatings. The reported here utilises radio frequency magnetron sputtering deposit both CaP and Sr-containing their characterisa...

The aim of this study was to evaluate the effect of desensitizing agents on the bond strength of different adhesive systems condition and rinse and self-etching to dentin through microshear. Sixty dentin fragments were used, obtained from the buccal and lingual surfaces of molars third molars, which were distributed in groups (n = 12) according to desensitizing treatment (control no treatment; ...

The deposition of thin films bioactive materials is the most common approach to improve bone bonding ability an implant surface. With this purpose, several wet and plasma assisted methods were proposed in scientific literature. In review, we considered obtained by nanosecond Pulsed Laser Deposition (PLD). Since hydroxyapatite (HA) has composition structure similar that mineral component bone, i...

Calcium phosphate materials (CaPs) are similar to inorganic part of human mineralized tissues (i.e., bone, enamel, and dentin). Owing to their high biocompatibility, CaPs, mainly hydroxyapatite (HA), have been investigated for their use in various medical applications. One of the most widely used ways to improve the biological and physicochemical properties of HA is ionic substitution with trac...