Previously, we reported the discovery of a series of N-hydroxycinnamamide-based HDAC inhibitors, among which compound 11y exhibited high HDAC1/3 selectivity. In this current study, structural derivatization of 11y led to a new series of benzamide based HDAC inhibitors. Most of the compounds exhibited high HDACs inhibitory potency. Compound 11a (with 4-methoxybenzoyl as N-substituent in the cap ...

We report the fluorination of electrically insulating hexagonal boron nitride (h-BN) and the subsequent modification of its electronic band structure to a wide bandgap semiconductor via introduction of defect levels. The electrophilic nature of fluorine causes changes in the charge distribution around neighboring nitrogen atoms in h-BN, leading to room temperature weak ferromagnetism. The obser...

With the intent of increasing the signal-to-noise ratio (SNR) of fluorine magnetic resonance imaging and enabling new applications, we have developed a novel class of agents based on protein encapsulation of fluorocarbons. Microspheres formed by high-intensity ultrasound have a gaussian size distribution with an average diameter of 2.5 microns. As with conventional emulsions, these microspheres...

The generated resist based defects on the template in addition to the presence of particles and contaminants is critical for ultraviolet curing of nanoimprint lithographic fabrication. This procedure is proven to be suitable for advanced resist material design under the process conditions. Nanoimprint resist material containing an ultraviolet reactive fluorine surfactant was developed to modify...

ion of fluorine atoms occurs for each of the projectile ions examined, with up to five fluorine atoms being abstracted by W, two F atoms being abstracted in the case of CI and PCl projectiles, and just one fluorine atom being abstracted by Si, P, I, and Br-containing ions (see Table 1). The maximum numbers of atoms abstracted in ion/surface reactions are similar [26–29], although the product io...

We investigated the possible adsorption of each main building blocks spider silk: alanine, glycine, leucine, and proline. This knowledge could help develop new biocompatible materials favors creation biosensors. used ab initio density functional theory methods to study variations in optical absorption, reflectivity, band structure a modified graphene surface interacting with these four molecule...

Chemical vapour deposition (CVD) of the superconducting 2:2:1:2 phase in the Bi-Sr-Ca-Cu-0 system from different metalorganic precursors is thermodynamically investigated. Both precursors without fluorine and fluorine-containing precursors were employed. The oxygen source was O, H,O, O,+H,O or N,O. The effect of different deposition parameters on the extension of the region where the 2:2:1:2 ph...

The purpose of this study was to develop a new method of releasing fluorine in a controlled manner for applications in the field of orthodontic Ti-based wire, namely the coating of fluorides on Ti. Thin films of two fluoride compounds, CaF(2) and MgF(2), were coated on Ti via the electron-beam evaporation method. The fluorine was released rapidly from the as-deposited MgF(2) coating within a sh...

Double-walled carbon nanotubes (DWCNTs) are fluorinated using (1) fluorine F2 at 200 °C, (2) gaseous BrF3 at room temperature, and (3) CF4 radio-frequency plasma functionalization. These have been comparatively studied using transmission electron microscopy and infrared, Raman, X-ray photoelectron, and near-edge X-ray absorption fine structure (NEXAFS) spectroscopy. A formation of covalent C-F ...

The structures and reactivity of fluoridated Keggin-aluminum tridecamers (K-Al13) in aqueous solution were studied using density functional theory (DFT) in order to explore the fluorine substitution process and the influence of F(-) on the chemical behavior of Keggin polynuclear Al species. The structures of fluoridated K-Al13 were optimized with the consideration of both explicit and bulk solv...