The presence of the translocator protein (TSPO), previously named as the mitochondrial or peripheral benzodiazepine receptor, in bone cells was studied in vitro and in situ using RT-qPCR, and receptor autoradiography using the selective TSPO ligand PK11195.In vitro, the TSPO is highly expressed in osteoblastic and osteoclastic cells.In situ, constitutive expression of TSPO is found in bone marr...

BACKGROUND This study compares the frequency and distribution of increased activity on 18 F-fluoride PET/CT with the presence of bone marrow edema on whole-body MR imaging in the spine and sacroiliac joints (SIJ) of patients with active ankylosing spondylitis (AS). METHODS Ten patients (6 men and 4 women), between 30 and 58 years old (median 44) with active AS, were prospectively examined wit...

1. Whole-body retention in vivo and uptake of 59Fe-labelled ascorbate and nitrilotriacetate chelates by intestinal slices in vitro were determined in groups of normal control rabbits and rabbits with experimentally-induced Fe deficiency. 2. Over-all absorption as measured by retention of doses of either chelate was greatly increased in conditions of Fe deficiency. 3. Intestinal Fe uptake in vit...

Wheat stands as a prominent cereal crop, holding significant importance in both food and production realms. In the cultivation of winter wheat within soil environments tainted with fluorine compounds, application mineral biological fertilizers becomes imperative. This amalgamation beneficial bacteria, coupled growth-stimulating properties, plays pivotal role averting uptake toxic substances by ...

OBJECTIVE To evaluate the prevalence of exclusive lower extremity metastases, specifically in the femur and below the knee, observed at (18)F-NaF PET/CT. MATERIALS AND METHODS One thousand consecutive PET/CT studies were retrospectively evaluated for the presence of exclusive uptake in lower extremities suggesting metastatic involvement. The presumptive diagnoses based on such uptakes were su...

To explore the role of GTPases in endocytosis, we developed an assay using Xenopus oocytes injected with recombinant proteins to follow the uptake of the fluid phase marker HRP. HRP uptake was inhibited in cells injected with GTPgammaS or incubated with aluminum fluoride, suggesting a general role for GTPases in endocytosis. Injection of Rab5 into oocytes, as well as Rab5:Q79L, a mutant with de...

tea is the second most commonly consumed beverage world wide. tea ( camellia sinensis ) is a naturally rich source of fluoride. the quantity of fluoride intake is important in optimizing its dental caries-preventive role. intense concentration of fluoride in tea, can lead to excessive fluoride intake which may cause health problems in turn. the measurement of fluoride intake usually requires in...

Despite a plethora of in situ studies and clinical trials evaluating the efficacy of fluoridated dentifrices on caries control, in vitro pH cycling models are still broadly used because they mimic the dynamics of mineral loss and gain involved in caries formation. This paper critically reviews the current literature on existing pH-cycling models for the in vitro evaluation of the efficacy of fl...