Cilia, as motile and sensory organelles, have been implicated in normal development, as well as diseases including cystic kidney disease, hydrocephalus and situs inversus. In kidney epithelia, cilia are proposed to be non-motile sensory organelles, while in the mouse node, two cilia populations, motile and non-motile have been proposed to regulate situs. We show that cilia in the zebrafish larv...

Drug transport and its uptake by tumour cells are strongly dependent on tumour properties, which vary in different types of solid tumours. By simulating the key physical and biochemical processes, a numerical study has been carried out to investigate the transport of anti-cancer drugs in 3-D tumour models of different sizes. The therapeutic efficacy for each tumour is evaluated by using a pharm...

PURPOSE The present study determined the association between body fluid variation and the development of acute mountain sickness (AMS) in adults. METHODS Forty-three healthy participants (26 males and 17 females, age: 26 ± 6 yr, height: 174 ± 9 cm, weight: 68 ± 12 kg) were passively exposed at a FiO2 of 12.6% (simulated altitude hypoxia of 4500 m, PiO2 = 83.9 mmHg) for 12-h. AMS severity was ...

Results T wenty-six patients were prospectively evaluated. Two patients had normal TBV at admission. Twenty-four patients were hypervolemic with TBV (7.4 1.6 liters) increased by þ39 22% (range, þ9.5% to þ107%) above the expected normal volume. With diuresis, TBV decreased marginally (þ30 16%). Body weight declined by 6.9 5.2 kg, and fluid intake/fluid output was a net negative 8.4 5.2 liters. ...

background and aims. changes in the balance of sexual hormones during pregnancy decrease gingival crevicular fluid levels of interleukin-6 and the resistance of gingival tissue against inflammations. hormonal contraceptives are agents that are based on the effects of gestational hormones and simulate a state of pregnancy; therefore, they prevent ovulation. this study evaluates the effect of the...

This paper address the problem of Bayesian estimation of the parameters, reliability and hazard function in the context of record statistics values from the two-parameter Lomax distribution. The ML and the Bayes estimates based on records are derived for the two unknown parameters and the survival time parameters, reliability and hazard functions. The Bayes estimates are obtained based on conju...

BACKGROUND Norepinephrine administration is controversial during hemorrhagic shock resuscitation to stabilize mean arterial pressure (MAP) level because it could have deleterious effects on local circulations. The authors investigated the effect of norepinephrine on intestinal microcirculation during fluid resuscitation in uncontrolled hemorrhagic shock. METHODS Mice (n = 6 per group) submitt...

1. M.D., D.A., Prof. in Anaesthesiology 2. M.D., D.A. (PDCC) Department of Anaesthesiology Amrita Institute of Medical Sciences and Research Center. Elamakkara, Cochin, Kerala 682 025 Correspond to : Dr. Suresh G. Nair E-mail: [email protected] Introduction Fluid management of the paediatric surgical patient is a critical element in the care of infants and children who are sensitive to sm...

The knowledge of solid loss kinetics of foods during digestion is crucial for understanding the factors that constrain the release of nutrients from the food matrix and their fate of digestion. The objective of this study was to investigate the solid loss of carrots during simulated gastric digestion as affected by pH, temperature, viscosity of gastric fluids, mechanical force present in stomac...

lung contusion is an entity involving injury to the alveolar capillaries, without any tear or cut in the lung tissue. this results in accumulation of blood and other fluids within the lung tissue. the excess fluid interferes with gas exchange leading to hypoxia. the pathophysiology of lung contusion includes ventilation/perfusion mismatching, increased intrapulmonary shunting, increased lung wa...