Vaccination, one of the most effective and cost-efficient strategy in preventing and controlling influenza virus infection, also has poorly immunogenicity and side effects. Thus, adjuvants are employed to augment the immune response and overcome the drawbacks of vaccine. Here, we present a novel Toll-like receptor agonist (SZU101, T7) to evaluate the adjuvanticity for inactivated H1N1 influenza...

In the course of modeling the naturally occurring tumor immunity seen in patients with paraneoplastic cerebellar degeneration (PCD), we discovered an unexpectedly high threshold for breaking CD8+ cytotoxic T cell (CTL) tolerance to the PCD autoantigen, CDR2. While CDR2 expression was previously found to be strictly restricted to immune-privileged cells (cerebellum, testes, and tumors), unexpect...

The seasonal influenza virus afflicts between 5 and 20 percent of the U.S. population each year, imposing significant costs on those who fall ill, their families, employers, and the health care system. The flu is transmitted via droplet spread or close contact, and certain environments, such as schools or offices, promote transmission. In this paper we examine whether increased employment rates...

BACKGROUND With the transition to hydrofluoroalkane-134a propellants in metered dose inhalers, it is important to consider the efficacy and safety profiles of formulations containing inhaled corticosteroids. We examined the airway and systemic effects of hydrofluoroalkane-134a fluticasone propionate (FLU-HFA) and beclomethasone dipropionate (BEC-HFA) at recommended labelled doses. METHODS Twe...

OBJECTIVES Annual vaccination against influenza (flu) is recommended for all UK National Health Service (NHS) staff to help reduce the risk of contracting the virus and transmitting it to patients. However, despite flu campaigns and vaccination promotion, uptake remains low. The aim of this study was to investigate staff attitudes to flu vaccination to see how this may influence their decision ...

BACKGROUND The inFLUenza Patient Reported Outcome (FLU-PRO) measure is a daily diary assessing signs/symptoms of influenza across six body systems: Nose, Throat, Eyes, Chest/Respiratory, Gastrointestinal, Body/Systemic, developed and tested in adults with influenza. OBJECTIVES This study tested the reliability, validity, and responsiveness of FLU-PRO scores in adults with influenza-like illne...

Since the beginning of January 2008 sporadic cases of infections in humans caused by influenza A (H1N1) virusresistant to available anti-influenza drugs have been reported worldwide [1,2]. The World Health Organization (WHO) in its report published on 18 March 2009 indicated that during weeks 1-4 (28 December 08-24 January 09), the level of overall influenza activity in the world increased. Dur...

conclusions since the severity of the behavioral symptoms in the 6-ohda-induced model of parkinson disease reflects the degree of the lesion in substantia nigra (sn) dopaminergic neurons, it is suggested that using the combination had neuroprotective effects. the obtained data suggest a synergistic neuroprotective and antiparkinsonian effect for flu, glib and b com. at least, a part of this eff...

Introduction / objectives In the US, immunization for many vaccine preventable illnesses are mandated as a condition of employment, but Influenza (flu) has not been mandatory. Despite 1986 Center for Disease Control recommendations that healthcare workers be vaccinated annually for flu, the US national average is 61.9%. Patient & employee safety / preventing nosocomial infections are central to...