Abstract Background and Aims Systemic Lupus Erythematosus (SLE) is characterized by a shift to senescent B cells, namely, switched memory (SM) (CD19+IgD-CD27+) exhausted-double negative (DN) (CD19+IgD-CD27-) subtypes. The aim of this study was evaluate the impact T cell immunity in distinct - pattern SLE. Method A wide range exhaustion related lymphocyte surface molecules, including CD45RA, CCR...

Objective: We aimed to evaluate the number and function of regulatory T (Treg) cells in peripheral blood prostate tissues patients with histopathologically diagnosed benign hyperplasia (BPH) asymptomatic chronic prostatitis.
 Material Methods: Blood histopathological data 19 (BPH=10, ACP=9) that underwent transurethral resection were evaluated. Treg cell count prostatic tissue flowcytometr...

Introduction: The p19 line of embryonal carcinoma cells develops into neurons, astroglia and fibroblasts after aggregation and exposure to retinoic acid (RA). Dehydroepiandroesteron (DHEA) is a neurosteroid, can increase proliferation of human neural stem cell (NSC) and positively regulated the number of neurons produced. This study was initiated to assess the effect of DHEA on neural progenito...

BACKGROUND Dendritic cells (DC) linking innate and adaptive immune responses are present in human lungs, but the characterization of different subsets and their role in COPD pathogenesis remain to be elucidated. The aim of this study is to characterize and quantify pulmonary myeloid DC subsets in small airways of current and ex-smokers with or without COPD. METHODS Myeloid DC were characteriz...

BACKGROUND & OBJECTIVES Chapekar established a model of ovarian tumourigenesis in mice by splenic transplantation of ovaries, resulting in sustained luteinizing hormone (LH) levels because of absence of feedback inhibition. There is increasing evidence of the differential response to LH or hCG under various experimental conditions. The effect of sustained hormonal stimulation in long term cultu...

OBJECTIVE IL-22 is elevated in patients with inflammatory arthritis and correlates with disease activity. IL-22 deficient mice have reduced incidence of arthritis. Recombinant IL-22 restrains progression of arthritis via increase in IL-10 responses when administered prior to onset of arthritis. These findings imply a possible dual role of IL-22 in inflammatory arthritis depending on the phase o...

regulation of normal cell growth and turnover is balanced between cell pro¬liferation, cell differentiation and apoptosis. a disruption of this balance is thought to be an important event leading to carcinogenesis .one of the effector molecules in apoptosis is fas antigen . cross-linking of fas by its ligand (fas l) or agonistic anti fas antibodies induces apoptosis of cells expressing fas on t...