Organomanganese reagents were prepared by the insertion of magnesium into aryl halides in the presence of MnCl2·2LiCl. These organomanganese reagents smoothly undergo 1,2-addition, acylation, and Pd-catalyzed cross-coupling with various electrophiles. Especially, the oxidative homocoupling of organomanganese reagents was completed in one pot without an additional transition-metal catalyst.

Optimal control experiments can readily identify effective shaped laser pulses, or "photonic reagents," that achieve a wide variety of objectives. An important additional practical desire is for photonic reagent prescriptions to produce good, if not optimal, objective yields when transferred to a different system or laboratory. Building on general experience in chemistry, the hope is that trans...

Use of the appropriate quality of reagents is clearly important if immunoassays are to be optimised. Some reagents can affect the sensitivity and specificity of immunoassays and so quite different results may be obtained if reagents are not of comparable quality and purity. Particularly important is the quality of immunoglobulin reagents used in immuno-assays. It is necessary to purify the IgG ...

The synthesis of long-arm thiolated beads from beaded polyacrylamide ( $400 mesh, 10-37^ M diameter, 2,000 Dalton inclusion limit) is described. The long spacer arm, polyethylene glycol di(3-mercapto-propionate)(PEG-DMP) was i introduced via thioether formation with haloacetamidoethyl beads. The latter were prepared via the N-hydroxysuccinimide ester (NHS) after surveying a number of peptide co...

In search of alternatives to unstable or unreliable 2-pyridylboron reagents, we have explored two new varieties of solid, moderately air-stable 2-pyridylzinc reagents. Both reagents can be manipulated in air and are competent nucleophiles in Negishi cross-coupling reactions.

The purpose of this investigation was directed to propose sensitive, accurate and reproducible methods of analysis that can be applied to determine distigmine bromide (DTB), cyclopentolate hydrochloride (CPHC), diaveridine hydrochloride (DVHC) and tetrahydrozoline hydrochloride (THHC) drugs in pure form and pharmaceutical preparations via charge-transfer complex formation with 7,7,8,8-tetracyan...