nowadays, cardiovascular diseases are the most important cause of death. one of the reasons of cardiovascular diseases is poor nutrition, such as high intake of saturated fatty acids and low intake of essential and unsaturated fatty acids. among the oilseeds, flaxseed contains high amount of essential fatty acids, tochopherol, fiber and lignans. grape molasses is a traditional food in iran and ...

The rapid rate of postmenopausal bone loss is mediated by the inflammatory cytokines interleukin-1, interleukin-6, and tumor necrosis factor alpha. Dietary supplementation with fish oil, flaxseeds, and flaxseed oil in animals and healthy humans significantly reduces cytokine production while concomitantly increasing calcium absorption, bone calcium, and bone density. Possibilities may exist for...

Background: Nutraceuticals are in high demand as dietary supplements on the international market since decades. Nutritional and therapeutic called nutraceuticals widely accessible. Alpha linolenic acid (ALA), fibre, proteins, vital omega-3 fatty acids all present concentrations flaxseed, one of oldest most utilised food supplements. The work was aimed to formulate develop flaxseed oil beads con...

The central dogma of nanoemulsion formation using low-energy methods at constant temperature-popularly known as the emulsion inversion point (EIP) method-is that to create O/W nanoemulsions, water should be added to a mixture of an oil and surfactant. Here, we demonstrate that the above order of mixing is not universal and a reverse order of mixing could be superior, depending on the choice of ...

The aim of the present study was to investigate the potential of a nanoemulsion formulation for topical delivery of aceclofenac. Various oil-in-water nanoemulsions were prepared by the spontaneous emulsification method. The nanoemulsion area was identified by constructing pseudoternary phase diagrams. The prepared nanoemulsions were subjected to different thermodynamic stability tests. The nano...

The impact of curcumin-loaded nanodroplets on the properties commercial salad dressings was examined. Nanoemulsions were formulated using a plant-based oil (medium chain triglycerides, MCT) and either (Quillaja saponaria, QS) or animal-based (whey protein isolate, WPI) emulsifier. Curcumin-loaded nanoemulsions produced by microfluidization contained small anionic droplets: d32 = 0.28 0.11 μm ζ ...

We summarize procedures for producing ‘nanoemulsions’ comprised of nanoscale droplets, or ‘nanoemulsions’, methods for controlling the droplet size distribution and composition, and interesting physical properties of nanoemulsions. In contrast to more common microscale emulsions, nanoemulsions exhibit optical transparency at high droplet volume fractions, φ, surprisingly strong elasticity at lo...

Nanoemulsions have been widely applied to dermal and transdermal drug delivery. However, whether and to what depth the integral nanoemulsions can permeate into the skin is not fully understood. In this study, an environment-responsive dye, P4, was loaded into nanoemulsions to track the transdermal translocation of the nanocarriers, while coumarin-6 was embedded to represent the cargoes. Particl...

Although the fish-derived, long-chain omega-3 fatty acids (n-3 FA) may be considered “gifts from the sea” for cardiovascular health, the role of the land (or plant) -based n-3 FA -linolenic acid (ALA) has been less clear. ALA is the 18-carbon, 3-double bond (C18:3n-3) precursor to eicosapentaenoic acid (EPA; C20:5n-3) and docosahexaenoic acid (DHA; C22:6n-3), the latter 2 being the predominant ...

This study focuses on the development of biocompatible oil-in-water (O/W) nanoemulsions based polyglycerol esters, as promising carriers for natural actives: red raspberry seed oil—RO and hydro-glycolic fruit extracts from raspberry—RE French oak—FE. Nanoemulsions were obtained via phase inversion composition (PIC) method at room temperature by dilution microemulsion phase, confirmed visual app...