Mammalian Ether-a-go-go related gene (Erg) family voltage-gated K(+) channels possess an unusual gating phenotype that specializes them for a role in delayed repolarization. Mammalian Erg currents rectify during depolarization due to rapid, voltage-dependent inactivation, but rebound during repolarization due to a combination of rapid recovery from inactivation and slow deactivation. This is ex...

mutation or TMPRSS2‐ERG fusions induced proliferation and invasion in prostate cancer cells. This study along with a recently published similar report provides two previously unrecognized mechanisms for the upregulation of ERG proteins frequently observed in prostate cancers. These findings generate great enthusiasm for the development of targeted therapeutic strategies designed to eliminate ER...

Abstract We report on a one-second-cadence wide-field survey for M-dwarf flares using the Tomo-e Gozen camera mounted Kiso Schmidt telescope. detect 22 from M3–M5 dwarfs with rise time of 5 s ? trise 100 and an amplitude 0.5 ?F/F? 20. The flare light-curves mostly show steeper rises shallower decays than those obtained Kepler one-minute cadence data tend to have flat peak structures. Assuming b...

T cell vaccination (TCV) activates Tregs of 2 kinds: anti-idiotypic (anti-id) and anti-ergotypic (anti-erg). These regulators furnish a useful view of the physiology of T cell regulation of the immune response. Anti-id Tregs recognize specific effector clones by their unique TCR CDR3 peptides; anti-id networks of CD4+ and CD8+ Tregs have been described in detail. Here we shall focus on anti-erg...

In monolayer culture, primary articular chondrocytes have an intrinsic tendency to lose their phenotype during expansion. The molecular events underlying this chondrocyte dedifferentiation are still largely unknown. Several transcription factors are important for chondrocyte differentiation. The Ets transcription factor family may be involved in skeletal development. One family member, the Erg ...

Purpose Recent evidence suggests structural changes distal to the inner retina in multiple sclerosis (MS) patients. The functional correlates of these proposed structural abnormalities remain unclear. We investigated outer retinal function and structure in MS patients, and quantified to what extent outer retinal structure influenced function in these patients. Methods Outer retinal function w...

Understanding fundamental molecular mechanisms that govern the transmigration and interstitial migration of leukocytes to sites of tissue damage and infection is of potential significance in identifying novel therapeutic targets for the management of chronic inflammatory disorders. CD31 is a mammalian cell adhesion molecule that regulates the recruitment of leukocytes from the circulation. Our ...

A short Chandra ACIS-S observation of the Seyfert 2 galaxy IC 2560, which hosts a luminous nuclear water megamaser, shows: 1) the X-ray emission is extended; 2) the X-ray spectrum shows emission features in the soft (E < 2 keV) X-ray band; this is the major component of the extended emission; and 3) a very strong (EW∼ 3.6 keV) iron Kα line at 6.4 keV on a flat continuum. This last feature clear...

Downloa RSS2-ERG and other gene fusions involving ETS factors and genes with strong promoter elements are on in prostate cancer. Although ERG activation has been linked to invasive properties of prostate canhe precise mechanisms and pathways of ERG-mediated oncogenesis remain poorly understood. Here, we that ERG knockdown in VCaP prostate cancer cells causes an activation of cell adhesion, resu...