نتایج جستجو برای: fission

تعداد نتایج: 14853  

Journal: :The Journal of Cell Biology 2000
Quinton Tieu Jodi Nunnari

Mitochondrial fission is mediated by the dynamin-related GTPase, Dnm1p, which assembles on the mitochondrial outer membrane into punctate structures associated with sites of membrane constriction and fission. We have identified additional nuclear genes required for mitochondrial fission, termed MDV (for mitochondrial division). MDV1 encodes a predicted soluble protein, containing a coiled-coil ...

2017
Jung-Hak Kim Sun-Ji Park Bokyung Kim Young-Geun Choe Dong-Seok Lee

Adipocyte differentiation is regulated by intracellular reactive oxygen species (ROS) generation and mitochondrial fission and fusion processes. However, the correlation between intracellular ROS generation and mitochondrial remodeling during adipocyte differentiation is still unknown. Here, we investigated the effect on adipocyte differentiation of 3T3-L1 cells of intracellular ROS inhibition ...

Journal: :Annales UMCS, Informatica 2003
Andrzej Baran

The shortest path problem is solved and applied to the calculations of half lives with respect to spontaneous fission of heavy nuclei. The dynamical programming method of Bellman and Kalaba is used to find the fission path in the d-dimensional space of deformation parameters. Fission half lives of heavy isotopes (100<Z<110) are shown and compared to the experimental data. 1. Introductory remark...

2017
Shin-ichi Arimura Rina Kurisu Hajime Sugaya Naoki Kadoya Nobuhiro Tsutsumi

The number, size and shape of polymorphic plant mitochondria are determined at least partially by mitochondrial fission. Arabidopsis mitochondria divide through the actions of a dynamin-related protein, DRP3A. Another plant-specific factor, ELM1, was previously shown to localize DRP3A to mitochondrial fission sites. Here, we report that mitochondrial fission is not completely blocked in the Ara...

2014
Qinfang Shen Koji Yamano Brian P. Head Sumihiro Kawajiri Jesmine T. M. Cheung Chunxin Wang Jeong-Hoon Cho Nobutaka Hattori Richard J. Youle Alexander M. van der Bliek

Mitochondrial fission is mediated by the dynamin-related protein Drp1 in metazoans. Drp1 is recruited from the cytosol to mitochondria by the mitochondrial outer membrane protein Mff. A second mitochondrial outer membrane protein, named Fis1, was previously proposed as recruitment factor, but Fis1(-/-) cells have mild or no mitochondrial fission defects. Here we show that Fis1 is nevertheless p...

2008
Filippo Aureli Colleen M. Schaffner Christophe Boesch Simon K. Bearder Josep Call Colin A. Chapman Richard Connor Anthony Di Fiore Robin I. M. Dunbar S. Peter Henzi Kay Holekamp Amanda H. Korstjens Robert Layton Phyllis Lee Julia Lehmann Joseph H. Manson Gabriel Ramos Karen B. Strier Carel P. van Schaik Roberto Cozzolino FILIPPO AURELI John Moores James Parsons COLLEEN M. SCHAFFNER SIMON K. BEARDER COLIN A. CHAPMAN ROBIN I. M. DUNBAR AMANDA H. KORSTJENS JOSEPH H. MANSON GABRIEL RAMOS-FERNÁNDEZ KAREN B. STRIER CAREL P. VAN SCHAIK

Nineteen scientists from different disciplines collaborated in highlighting new methodological and theoretical aspects in the re-emerging study area of fission-fusion dynamics. The renewed interest in this area is due to the recognition that such dynamics may create unique challenges for social interaction and distinctive selective pressures acting on underlying communicative and cognitive abil...

Journal: :The Journal of Cell Biology 1998
Phil Oh Deirdre P. McIntosh Jan E. Schnitzer

The molecular mechanisms mediating cell surface trafficking of caveolae are unknown. Caveolae bud from plasma membranes to form free carrier vesicles through a "pinching off" or fission process requiring cytosol and driven by GTP hydrolysis (Schnitzer, J.E., P. Oh, and D.P. McIntosh. 1996. Science. 274:239-242). Here, we use several independent techniques and functional assays ranging from cell...

2013
J.-F. Lemaître N. Dubray S. Hilaire S. Panebianco J.-L. Sida

Our purpose is to determine fission fragments characteristics in a framework of a scission point model named SPY for Scission Point Yields. This approach can be considered as a theoretical laboratory to study fission mechanism since it gives access to the correlation between the fragments properties and their nuclear structure, such as shell correction, pairing, collective degrees of freedom, o...

2017
Valentina Galli Rafael Sebastian Sandrine Moutel Jason Ecard Franck Perez Aurélien Roux

Dynamin is a large GTPase that forms a helical collar at the neck of endocytic pits, and catalyzes membrane fission (Schmid and Frolov, 2011; Ferguson and De Camilli, 2012). Dynamin fission reaction is strictly dependent on GTP hydrolysis, but how fission is mediated is still debated (Antonny et al., 2016): GTP energy could be spent in membrane constriction required for fission, or in disassemb...

Journal: :Cell 2004
Christopher Peters Tonie L. Baars Susanne Bühler Andreas Mayer

Membrane fusion and fission are antagonistic reactions controlled by different proteins. Dynamins promote membrane fission by GTP-driven changes of conformation and polymerization state, while SNAREs fuse membranes by forming complexes between t- and v-SNAREs from apposed vesicles. Here, we describe a role of the dynamin-like GTPase Vps1p in fusion of yeast vacuoles. Vps1p forms polymers that c...

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