Experiments indicate that unbinding rates of proteins from DNA can depend on the concentration of proteins in nearby solution. Here we present a theory of multistep replacement of DNA-bound proteins by solution-phase proteins. For four different kinetic scenarios we calculate the dependence of protein unbinding and replacement rates on solution protein concentration. We find (1) strong effects ...

PURPOSE Aberrant DNA methylation occurs in a subset of colorectal cancers and is characterized by regional areas of hypermethylation at CpG islands. The aims of this study were firstly to evaluate the levels of folate intermediates (FIs) in tumors with aberrant DNA methylation and secondly to determine whether these levels are affected by polymorphisms in key genes involved in folate metabolism...

Aufgrund einer Abwendung der Aufmerksamkeit kann die Bedienung von Fahrerinformationssystemen (FIS) während der Fahrt zu Einbußen in der Fahrsicherheit führen: Es kommt zu Interferenzen zwischen Fahrzeugführung und FIS-Bedienung. Als Erklärungsansatz für solche Interferenzeffekte wird regelhaft auf Kapazitätsoder Ressourcenmodelle zurückgegriffen, die z.B. von einer begrenzten kognitiven Verarb...

A Feral Information Systems (FIS) is any technological artefact (e.g. spreadsheets) that end users employ instead of the mandated Enterprise System (ES). ES proponents suggest that the installation of an ES will boost productivity. However, Production Possibility Frontier theory provides insights as to why the introduction of an ES may instead suppress an end user's productivity. Structuration ...

This study examined sources of therapist effects in a sample of 25 therapists who saw 1,141 clients at a university counseling center. Clients completed the Outcome Questionnaire-45 (OQ-45) at each session. Therapists' facilitative interpersonal skills (FIS) were assessed with a performance task that measures therapists' interpersonal skills by rating therapist responses to video simulations of...

Considering the digitalization of the economy, process-oriented quality management (PQM) has increasingly been gaining attention. In the course of a PQM project, quality techniques are applied to elicit employees’ process knowledge and transform it into solutions to overcome process weaknesses. However, quality techniques may support each other during application or produce contradictory result...

In this study, the application of type-1 and type-2 fuzzy inference system (FIS) in semi-active seismic vibration control of the College Bridge using magnetorheological (MR) dampers is investigated. For this purpose, a detailed 3D finite element model of the bridge fitted with MR dampers is created in OpenSees. The command voltage of MR dampers is determined by employing both types of FISs in M...

This paper examines whether foreign investors (FIs) affect the information production of analysts. Based on China's stock market, we find that FIs significantly reduce analysts’ coverage. Such negative association is more pronounced in firms with a high level governance and disclosure varies analyst characteristics. We also identify two possible economic mechanisms: channel channel. Further tes...

The binding of transcription factors (TFs) to DNA controls most aspects of cellular function, making the understanding of their binding kinetics imperative. The standard description of bimolecular interactions posits that TF off rates are independent of TF concentration in solution. However, recent observations have revealed that proteins in solution can accelerate the dissociation of DNA-bound...