I examine the determinants of con‡ict and settlement by embedding probabilistic contests in a bargaining framework. Di¤erent costly enforcement e¤orts (e.g., arming, litigation expenditures) induce di¤erent disagreement points and Pareto frontiers. After examining the incentives for settlement, I demonstrate how di¤erent division rules and bargaining norms have real, economic e¤ects. I then ana...

In this issue of Blood, Dany et al demonstrate a critical role of the ceramideregulated signaling pathway in inducing mitophagy to cause cell death and overcome drug resistance of acute myeloid leukemia (AML) cells carrying internal tandem duplication (ITD) of the Fms-like tyrosine kinase 3 (FLT3) gene. Inhibition of FLT3-ITD signaling through altering ceramide-involved lipid metabolism provide...

Fighting HIV/AIDS structure of a transcription initiation complex is solved, and we can visualize the interacting components. Gal1 also gives the authors a way to segue into the concept Staying Alive of sequential recruiting. Thus, the initial activators of Onward to higher eukaryotes and a variety of regulatory pathways. To show directly that mechanisms de-Less than a decade after the fall of ...

Children are vulnerable to extracranial solid tumours, known as neuroblastomas, at a very young age. These tumors are derived from primitive sympathetic neural precursors and they account for almost 15% of all pediatric cancer deaths (1). The most distinguishing feature of these tumors is their heterogeneous clinical behavior, which can range from spontaneous regression to highly aggressive met...

“I was now a resident, or rather an inmate, of the hospital,” says a mental health service user, of their experience in an institution. “I saw no one except the other people on the floor, who wore identical striped hospital robes and plastic bracelets with identifying names. The mental health workers were the only ones who could open the locked door. I left my hope on the other side of the lock...

flexibility and self-direction but also its daunting stress levels, has been both a blessing and a burden in my battle with depression. Depression, in turn, has not made it any easier to meet the challenges of academic life. I am fortunate to work in a department and at an institution that see younger faculty members as individuals to be invested in and supported. But the cost of depression to ...

Small size inocula (101-103 cells) of cells from a syngeneic methylcholanthrene-induced fibro-sarcoma (FSA) induced tolerance when injected s.c. into C3Hf mice. Mice were unable to respond to subsequent challenge with moderate, immunogenic doses of FSA. Tolerance was demonstrated in an in vivo transfer (Winn) assay and an in vitro tumour-specific TH cell assay. Low zone tolerance was associated...

One of the most promising strategies to treat cancer is attacking it with viruses. Virus can kill tumor cells specifically or act as carriers that deliver normal genes into cancer cells. A model for virus therapy of cancer is investigated and some of its predictions are in agreement with results obtained from experimental tumors. Furthermore, the model reveals an oscillatory (periodic or aperio...