it has been recognized that patients with cyanotic congenital heart disease (cchd) show significant bleeding tendency which can be secondary to coagulopathies in these patients. some coagulation abnormalities are thrombocytopenia, factor deficiencies, fibrinolysis and disseminated intravascular coagulation  (dic). according to high prevalence of cchd and major operations in theses patients, the...

ECENT YEARS have brought increased appreciation of the importance of the role of fibrinolysis in the regulation of normal hemostasis and in the production of abnormal bleeding. The mechanisms by which active fibrinolysis is induced are far from clear, but it does seem likely that it can be brought about by shock,1 severe emotional stress,2 injection of adrenalin,2 anoxia3 and liberation of acti...

A method is described for distinguishing coagulation from fibrinolysis by three estimates of fibrinogen. This "fibrinogen series" together with plasma antithrombin and urinary urokinase have been compared in pregnant patients with venous thrombosis and pre-eclampsia. Evidence is presented for active coagulation during deterioration of the pre-eclampsia state and for enhanced fibrinolysis during...

CONTEXT For patients with suspected acute myocardial infarction, decisions about fibrinolytic therapy must account for trade-offs between risks and benefits, which vary according to the clinical characteristics of the patient. OBJECTIVE To assess whether use of a decision-support computer program (DSCP) improves the selection of appropriate candidates for fibrinolytic therapy among patients w...

BACKGROUND AND OBJECTIVES The case of a patient with thrombotic manifestations and severe activated protein C resistance due to an anti-factor V antibody has recently been described. Since activated protein C (APC) is also profibrinolytic we wanted to determine whether the presence of antibodies interfering with the anticoagulant activity of APC also inhibits its profibrinolytic effect. DESIG...

BACKGROUND Improving timely access to reperfusion is a major goal of ST-segment-elevation myocardial infarction care. We sought to compare the population impact of interventions proposed to improve timely access to reperfusion therapy in Australia. METHODS AND RESULTS Australian hospitals, population, and road network data were integrated using Geographical Information Systems. Hospitals were...

Introduction An early activation of coagulation and fibrinolysis occurs during sepsis and results in a marked increase of thrombin and fibrin formation, leading to the syndrome of disseminated intravascular coagulation (DIC). DIC is a strong predictor of death and multiple organ failure in patients with septic shock [1]. Obesity has been demonstrated to be a hypercoagulable [2] and hypofibrinol...

In several clinical disorders, there are interactions between inflammation-dependent tissue injury and thrombin formation, fibrin deposition, and impaired fibrinolysis. New evidence generated from a mouse model of allergic airway hyperreactivity suggests that disordered coagulation and fibrinolysis may contribute to the pathogenesis of asthma. The inflammatory mechanisms that lead to airway smo...