objective:  to assess whether non-surgical periodontal treatment is associated with changes in serological markers of systemic inflammation. materials and methods: thirty-five systemically healthy subjects with severe generalized periodontitis meeting the inclusion criteria participated in a four-month single blind interventional trial of which thirty-two completed the study. periodontal parame...

Although 125I-fibrinogen becomes associated with washed platelets from normal human subjects during ADP-induced shape change and aggregation, 125I-fibrinogen did not become associated with washed plateletes from a thrombasthenic subject during ADP-induced shape change and the platelets did not aggregate. Platelets from control and thrombasthenic subjects were treated with chymotrypsin, which is...

Fibrinogen is a critical protein for clot formation, providingamatrix and mesh network essential for clot strength. Maintaining fibrinogen levels is an important therapeutic target in bleeding patients, particularly in perioperative settings. Early studies demonstrated that fibrinogen repletion corrected clot strength, based on viscoelastic blood testing using thromboelastography/thromboelastom...

This review of published studies was conducted to derive data on patients with congenital fibrinogen deficiency (CFD), including dosing of fibrinogen replacement therapy, outcome, and adverse events, either temporally related or distant to fibrinogen replacement, in order to assist clinicians in developing treatment plans for patients with CFD. A systematic review was performed of case reports ...

The ligand binding domain of the fibrinogen binding protein from Staphylococcus lugdunensis (Fbl) shares 60% sequence identity with clumping factor A (ClfA) of Staphylococcus aureus. Recombinant Fbl corresponding to the minimum fibrinogen-binding region (subdomains N2N3) was compared to ClfA for binding to fibrinogen. Fbl and ClfA had very similar affinities for fibrinogen by surface plasmon re...

Platelet activation by polymer surfaces is thought to require preliminary adsorption of fibrinogen and perhaps changes in fibrinogen conformation. We measured fibrinogen adsorption by a series of polymers by two methods. using either 125l-labeled fibrinogen or 125l-Iabeled antifibrinogen antibodies. and correlated the results with platelet reactivity (retention and secretion) in columns of bead...

1. Fibrinogen catabolism was studied in ten rabbits before and after suddenly elevating the intravascular pool by injecting a single dose of homologous fibrinogen equivalent to 1843% of the corresponding protein already present in this pool. Of the two metabolic tracers used, [13'I]fibrinogen was injected 3 4 days before and [1251]fibrinogen at the time of introducing the change. 2. Analysis of...

Plasma fibrinogen level represents a strong cardiovascular risk factor and is regulated by an interplay of genetic and environmental factors. Hyperfibrinogenemia frequently occurs in cluster with dyslipidemia within the frame of insulin resistance syndrome (IRS) and type 2 diabetes mellitus. Genetic variants with a pleiotropic effect have been proposed to cause IRS features including hyperfibri...

Human platelets incubated with a-chymotrypsin or pronase did not aggregate with ADP or thrombin and did not agglutinate with ristocetin. On the other hand, they aggregated with fibrinogen even in the absence of platelet-activating compounds. This aggregation was not inhibited by prostaglandin El, sodium azide, or formaldehyde, indicating that it was independent of platelet metabolism. Calcium o...

Fibrinogen from normal platelets and plasma was compared with material derived from a subject with the congenital fibrinogen abnormality termed fibrinogen Paris I. The molecular abnormality in this subject is characterized by the presence (in plasma molecules) of relatively large mutant ‘y-chains (‘y-Paris I) that replace 50% or more of the normal “y-chain population and that, unlike normal ‘y-...