نتایج جستجو برای: fgf

تعداد نتایج: 7537  

Journal: :Nefrologia : publicacion oficial de la Sociedad Espanola Nefrologia 2015
Baris Eser Ozlem Yayar Mehmet Buyukbakkal Bulent Erdogan Zafer Ercan Ozgur Merhametsiz Ayhan Haspulat Ebru Gök Oğuz İbrahim Dogan Basol Canbakan M Deniz Ayli

BACKGROUND Fibroblast growth factor 23 (FGF-23) is a phosphorus-regulating hormone. In chronic kidney disease (CKD), circulating FGF-23 levels are markedly elevated and independently associated with mortality. Left ventricular hypertrophy (LVH) is a potent risk factor for mortality in CKD, and FGFs have been implicated in the pathogenesis of myocardial hypertrophy. In addition, the effect of an...

2013
Birgitte Lindegaard Thine Hvid Thomas Grøndahl Christian Frosig Jan Gerstoft Pernille Hojman Bente Klarlund Pedersen

BACKGROUND Fibroblast growth factor (FGF)-21 is a novel regulator of glucose and lipid metabolism. Recently, increased FGF-21 mRNA expression in muscle was found in patients with type 2 diabetes, but the role for FGF-21 in muscle is not well understood. Patients with HIV-infection and lipodystrophy are characterised by various degree of lipid-driven insulin resistance. We hypothesized that musc...

Journal: :BJU international 2002
G O Hellawell S F Brewster

Prostate cancer is the most common malignancy in men in the USA and the second leading cause of cancer deaths. Fibroblast growth factors (FGFs), including FGF1 (acidic FGF), FGF2 (basic FGF), FGF6 and FGF8 are all expressed at increased levels in prostate cancer as paracrine and/or autocrine growth factors for the prostate cancer cells. In addition, increased mobilization of FGFs from the extra...

Journal: : 2023

ABSTRACT. The activity and duration of the inflammatory process in myocarditis affects severity course determines development cardiomyofibrosis, arrhythmias, dilatation syndrome, occurrence progression heart failure. mechanisms that affect transition from an active to chronic ventricular dysfunction have not yet been elucidated. Aim. To study peculiarities acute impact on quality life patients,...

Journal: :Clinical cancer research : an official journal of the American Association for Cancer Research 2013
Ronald S Go Sandra J Lee Donghoon Shin Steven M Callister Dean A Jobe Robert M Conry Ahmad A Tarhini John M Kirkwood

PURPOSE We investigated the use of graded-dose peginterferon α-2b (Peg-IFN) in patients with stage IV melanoma overexpressing basic fibroblast growth factor (FGF-2). The primary objective was suppression of plasma FGF-2 to within reference range (≤ 7.5 pg/mL). EXPERIMENTAL DESIGN Plasma FGF-2 was measured at baseline (step 1), and patients with concentrations of 15 pg/mL or more were eligible...

2000
Reju M. Korah Vilayvanh Sysounthone Yosef Golowa Robert Wieder

Basic fibroblast growth factor (FGF-2) expression is associated with a more differentiated phenotype, earlier stage of disease, and a better prognosis in breast cancer patients. To determine whether expression of FGF-2 can cause a less malignant phenotype, we engineered MDA-MB231 cells, a highly dedifferentiated, invasive breast cancer cell line, to express different isoforms of FGF-2. Cells ex...

Journal: :Arteriosclerosis, thrombosis, and vascular biology 2012
Jessica I Mollmark Andrew J-H Park Justin Kim Thomas Z Wang Sarah Katzenell Samantha L Shipman Lyubomir G Zagorchev Michael Simons Mary Jo Mulligan-Kehoe

OBJECTIVE Vasa vasorum are angiogenic in advanced stages of human atherosclerosis and hypercholesterolemic mouse models. Fibroblast growth factor-2 (FGF-2) is the predominant angiogenic growth factor in the adventitia and plaque of hypercholesterolemic low-density lipoprotein receptor-deficient/apolipoprotein B(100/100) mice (DKO). FGF-2 seems to play a role in the formation of a distinct vasa ...

Journal: :American journal of physiology. Renal physiology 2009
Radovan Vasko Michael Koziolek Masami Ikehata Maria Pia Rastaldi Klaus Jung Holger Schmid Matthias Kretzler Gerhard Anton Müller Frank Strutz

Basic fibroblast growth factor (FGF-2) plays a role in renal fibrogenesis, although its potential implications for tubulointerstitial involvement in diabetic nephropathy are unknown. We evaluated the expression of FGF-2 in kidney biopsies from patients with diabetic nephropathy and studied the mechanisms of its induction in human renal fibroblasts under hyperglycemia. Tubulointerstitial express...

Journal: :Arteriosclerosis, thrombosis, and vascular biology 2007
Bernhard H Rauch Godehard A Scholz Dana Baumgärtel-Allekotte Petra Censarek Jens W Fischer Artur-Aron Weber Karsten Schrör

OBJECTIVE The mitogenic response to the G protein-coupled receptor agonist thrombin in human vascular smooth muscle cells (SMCs) depends on release of fibroblast growth factor-2 (FGF-2). Yet, intracellular mechanisms triggering FGF-2 release are unknown. The present study investigates possible effects of cholesterol enrichment and depletion, which have been shown to influence FGF-2-dependent si...

Journal: :The Journal of biological chemistry 2014
Lindsay M Coe Sangeetha Vadakke Madathil Carla Casu Beate Lanske Stefano Rivella Despina Sitara

Abnormal blood cell production is associated with chronic kidney disease (CKD) and cardiovascular disease (CVD). Bone-derived FGF-23 (fibroblast growth factor-23) regulates phosphate homeostasis and bone mineralization. Genetic deletion of Fgf-23 in mice (Fgf-23(-/-)) results in hypervitaminosis D, abnormal mineral metabolism, and reduced lymphatic organ size. Elevated FGF-23 levels are linked ...

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