Abstract Nuclear pore complexes (NPCs) regulate all molecular transport between the nucleus and cytoplasm in eukaryotic cells. Intrinsically disordered Phe-Gly nucleoporins (FG-Nups) line central conduit of NPCs to impart a selective barrier where large proteins are excluded unless bound receptor (karyopherin; Kap). Here, we assess “Kap-centric” NPC models, which postulate that Kaps participate...

We applied transmission electron microscopy and densitometric image analysis to measure the cell volume (V) and dry weight (DW) of single bacterial cells. The system was applied to measure the DW of Escherichia coli DSM 613 at different growth phases and of natural bacterial assemblages of two lakes, Piburger See and Gossenköllesee. We found a functional allometric relationship between DW (in f...

This study was conducted to investigate the effect of fenugreek and copper sulfate supplementation levels and their combinations in diets on productive, physiological performance, lipids profile in blood, liver or yolk, fertility and hatchability of Japanese quail for a period of 7 weeks (from 8 to 14 weeks). A total number of 162 mature Japanese quail birds were used in this study. Quail birds...

Fluorinated graphene/ultra high molecular weight polyethylene (FG/UHMWPE) composites were prepared by ultrasonic dispersion and hot pressing. The mechanical propertys and tribological property of pure UHMWPE and FG/UHMWPE composites were investigated by micro hardness tester and high-speed reciprocating friction tester. The wear volume of the sample was measured by the scanning electron microsc...

This review summarizes current knowledge on the structure, function, assembly and biomedical applications of the superfamily of adhesive fimbrial organelles exposed on the surface of Gram-negative pathogens with the classical chaperone/usher machinery. High-resolution three-dimensional (3D) structure studies of the minifibers assembling with the FGL (having a long F1-G1 loop) and FGS (having a ...

Purpose: Connective tissue growth factor (CTGF) is overexpressed in pancreatic ductal adenocarcinoma (PDAC) and facilitates local desmoplasia, tumor progression and metastasis in animal models. This study evaluated safety and initial efficacy of the anti-CTGF antibody FG-3019 in combination with gemcitabine and erlotinib in patients with previously untreated Stage III or Stage IV PDAC. Methods:...

Let G be a finite abelian group and F a field such that char(F) 6 | |G|. Denote by FG the group algebra of G over F. A (semisimple) abelian code is an ideal of FG. Two codes I1 and I2 of FG are G-equivalent if there exists an automorphism ψ of G whose linear extension to FG maps I1 onto I2. In this paper we give a necessary and sufficient condition for minimal abelian codes to be G-equivalent a...

PURPOSE. TO investigate flux through the polyol pathway in the clog lens by F-nuclear magnetic resonance (F-NMR) spectroscopy, using 3-fluoro-3-deoxy-D-glucose (3-FG) as a substrate. METHODS. 3-FG metabolism was monitored by F-NMR analysis. Dog lenses were incubated in Dulbecco's modified Eagle's medium containing 10 mM 3-FG. Enzymatic reductase and dehydrogenase activities were spectrophotomet...

PURPOSE To characterize Brn3a expression in adult albino rat retinal ganglion cells (RGCs) in naïve animals and in animals subjected to complete intraorbital optic nerve transection (IONT) or crush (IONC). METHODS Rats were divided into three groups, naïve, IONT, and IONC. Two-, 5-, 9-, or 14-day postlesion (dpl) retinas were examined for immunoreactivity for Brn3a. Before the injury, the RGC...

BACKGROUND The fusiform gyrus (FG), or occipitotemporal gyrus, is thought to subserve the processing and encoding of faces. Of note, several studies have reported that patients with schizophrenia show deficits in facial processing. It is thus hypothesized that the FG might be one brain region underlying abnormal facial recognition in schizophrenia. The objectives of this study were to determine...