BACKGROUND Previous studies have reported that artificial increases in circulating free fatty acid (FFA) levels might have adverse effects on the vasculature. However, whether or not this effect can be extrapolated to physiological variations in FFA levels has not been clarified. Given that FFAs exert a lipotoxic effect on pancreatic β-cells and might directly damage the arterial endothelium, w...

Metabolic impairments are a frequent hallmark of systemic lupus erythematosus (SLE). Increased serum levels of free fatty acids (FFA) are commonly found in these patients, although the underlying causes remain elusive. Recently, it has been suggested that factors other than inflammation or clinical features may be involved. The gut microbiota is known to influence the host metabolism, the produ...

BACKGROUND High-energy-density biofuels are typically derived from the fatty acid pathway, thus establishing free fatty acids (FFAs) as important fuel precursors. FFA production using photosynthetic microorganisms like cyanobacteria allows for direct conversion of carbon dioxide into fuel precursors. Recent studies investigating cyanobacterial FFA production have demonstrated the potential of t...

Carpentier, André, Steven D. Mittelman, Benoı̌t Lamarche, Richard N. Bergman, Adria Giacca, and Gary F. Lewis. Acute enhancement of insulin secretion by FFA in humans is lost with prolonged FFA elevation. Am. J. Physiol. 276 (Endocrinol. Metab. 39): E1055–E1066, 1999.—The in vivo effect of elevated free fatty acids (FFA) on b-cell function in humans remains extremely controversial. We examined, ...

Flufenamic acid (FFA) is a nonsteroidal anti-inflammatory drug (NSAID). It has anti-inflammatory and antipyretic properties. In addition, it modulates multiple channel activities. The mechanisms underlying the pharmacological actions of FFA are presently unclear. Given that AMP-activated protein kinase (AMPK) has both anti-inflammatory and channel-regulating functions, we examined whether FFA i...

MILLER, H. I., B. ISSEKUTZ, JR., P. PAUL, AND K. RODAHL. Effect of lad tic acid on plasma free fatty acids in pancreatectomized dogs. Am. J. Physiol. 207(6): 1226-1230. rg64.-Sodium lactate infusions into unanesthetized pancreatectomized dogs, with indwelling arterial and venous catheters, markedly decreased the plasma free fatty acid (FFA) level. Infusions of palmitate-rCl4 at constant rates s...

OBJECTIVE Relative to whites, African Americans have lower circulating triglycerides (TG) and greater highdensity lipoprotein cholesterol. The metabolic basis for this difference is not known. This study was conducted to test the hypothesis that insulin-induced suppression of free fatty acids (FFA) results in lower serum TG in African American versus white prepubertal children. RESEARCH METHO...

0001 One of the most intriguing questions in biology is how the many different types of cells in an organism can develop from a single cell, the fertilized egg. Nowhere is this question more pertinent than in the nervous system, where each neuron must be endowed with the correct receptors, neurotransmitters, and other crucial molecules to carry out its complex function—animal behavior. The spec...