A B S T R A C T Adrenal glands from early, mid, and late fetuses of rabbit, guinea pig, and rat, and from newborn animals of each species, were incubated for 1-4 h with and without 0.1 nM-1 ,uM ACTH, aor ,B-melanocyte-stimulating hormone (aMSH or ,3MSH). The effects of the peptides were measured on production of glucocorticoids, and on incorporation of labeled thymidine or leucine into DNA or p...

AIM To assess the eventual influence of low dose betamethasone throughout pregnancy on fetal growth. PATIENTS AND METHODS 320 patients - admitted to the Section of Obstetrics and Gynecology of Ferrara University from January 2005 to December 2010 - were subdivided in two groups: 160 patients affected by recurrent spontaneous abortion (Group A), treated by low dose of betamethasone (0.5 mg/dai...

Insulin-like growth factor I (IGF-I) has anabolic effects and is thought to be important in fetal development. The present study was designed to determine the dose response of recombinant human (rh) IGF-I on ovine fetal glucose and amino acid kinetics. Chronically catheterized fetal lambs were studied at 122-127 days gestation. The kinetics of leucine, phenylalanine, and glucose were measured b...

Rituximab is a chimeric murine/human-engineered immunoglobulin (Ig) G1 anti-CD20 monoclonal antibody, selectively depleting CD20-expressing cells in peripheral blood and lymphoid tissues. As part of the rituximab registration-enabling program for rheumatoid arthritis, cynomolgus monkey embryo-fetal development and pre- and postnatal developmental toxicity studies were performed. In both studies...

Comparison with the results of similar experiments in adult dogs showed that the fetal liver was almost as efficient as the adult liver in the uptake, conjugation, and excretion of tracer amounts of cholate-"C. The maximal rate of excretion of radiolabel attained by the fetus was somewhat slower than in the adult (82.8 ±1.4% and 96.1 ±4.0% [mean +SE] of the infusion rate, respectively), and the...

BACKGROUND In the present study, the aim is to examine the risk of fetal loss related to environmental 2,2',4,4',5,5'-hexachlorobiphenyl (CB-153) or 1,1-dichloro-2,2-bis(p-chlorophenyl)ethylene (p,p'-DDE) exposure. METHODS We related LC/MS/MS measurements of CB-153 and p,p'-DDE in serum samples to interview-data on previous fetal loss in populations of pregnant women from Poland, Ukraine and ...

BACKGROUND Hypothyroidism during pregnancy has been associated with impaired cognitive development and increased fetal mortality. During pregnancy, maternal thyroid hormone requirements increase. Although it is known that women with hypothyroidism should increase their levothyroxine dose during pregnancy, biochemical hypothyroidism occurs in many. In this prospective study we attempted to ident...

We read with great interest the case by Leyh and associates on prosthetic valvular thrombosis in a pregnant patient anticoagulated with low-molecular-weight heparin (LMWH) [1]. Their case confirms once more the inefficacy of heparins to protect the mother from prosthetic valve thrombosis during pregnancy [2]. The usual management of anticoagulation in pregnant women is stopping warfarin adminis...

background: the shielding methods in radiotherapy due to delivering an accurate radiation dose to cancer tissues and avoiding unnecessary dose to normal tissues are very important. these methods include lead standard blocks, individual molding and multi leaf collimator (mlc). the mlc method is not still common in iran radiotherapy centers. individual molding is better than the lead block shield...