in iranian traditional medicine, there are some report regarding the anticonvulsant effect of ferula gummosa boiss. in this study, anticonvulsant activity, neurological deficits and lethality of the root acetone extract of this plant were evaluated in mice. the extract exhibited dose-dependent prevention of tonic seizures induced by pentylenetetrazole (ed50 = 154.4 mg/kg). however, the extract ...

background: ferula persica has been used in traditional medicine for treatment of high blood pressure. in this study acute and chronic effect of aqueous f. persica extract on bp of hypertensive rats and its possible mechanism of action have been investigated. methods: eighty two male wistar rats were divided into 12 experimental groups. hypertension was induced by goldblatt method in the anesth...

Objective: Control of weight gain is an important strategy in reducing the diabetes incidence. Recently, herbal drugs have been used as a complementary and alternative medicinal care. This study was conducted to determine the effect of Ferula asafoetida on weight gain, fat accumulation, liver steatosis and leptin level. Materials and Methods: All rats of control and treatment groups received d...

objective: control of weight gain is an important strategy in reducing the diabetes incidence. recently, herbal drugs have been used as a complementary and alternative medicinal care. this study was conducted to determine the effect of ferula asafoetida on weight gain, fat accumulation, liver steatosis and leptin level. materials and methods: all rats of control and treatment groups received da...

OBJECTIVE(S) Based on knowledge from traditional herbal medicine, Ferula assa-foetida (asafoetida) has several therapeutic applications but there is less knowledge about its effect on neurons. MATERIALS AND METHODS In order to evaluate neuronal differentiation, neuronal like cells were stained against neuronal specific markers β-Tubulin III and MAP2. After establishment of neuronal differenti...

objective: ferula szowitsiana has been widely used for medicinal purposes around the world. the anti-oxidant effect of f.szowitsiana had been proved. the current study aims to determine the protective effects of galbanic acid, a sesquiterpene coumarin from f. szowitsiana, against hydrogen peroxide (h2o2) - induced oxidative dna damage in human lymphocytes. materials and methods: human lymphocyt...

several complications attributed with herpes virus related infections and the emergence of drug resistant viruses prompt scientists to search for new drugs. several terpenoids and coumarins have shown anti hsv effects while no sesquiterpene coumarin have been previously tested for hsv treatment. three sesquiterpene coumarins [badrakemin acetate (1), kellerin (2) and samarcandin diasteromer (3) ...