Fluid dynamic simulations using the FENE-P model of polymer physics are compared to those an incompressible Newtonian fluid base case in order understand role elasticity formation vortices a 90° bend narrow channel. The analysis bridges flow behavior purely elastic and that fluid. We evaluated how four dimensionless numbers—Reynolds number (Re), Weissenberg (Wi), viscosity ratio (?), (El)—affec...

ν = q · P M = E − E′ is the lepton’s energy loss in the nucleon rest frame (in earlier literature sometimes ν = q · P ). Here, E and E′ are the initial and final lepton energies in the nucleon rest frame. Q2 = −q2 = 2(EE′−−→k · −→k ′)−m2 −m2 ′ where m (m ′) is the initial (final) lepton mass. If EE′ sin2(θ/2) m2 , m2 ′ , then ≈ 4EE′ sin2(θ/2), where θ is the lepton’s scattering angle with respe...

Two epitopes have been identified recently to be responsible for the high-affinity binding of alkane-bisammonium and caracurine V type allosteric ligands to N-methylscopolamine (NMS)-occupied M2 muscarinic acetylcholine receptors, relative to M5 receptors: the amino acid M2-Thr423 at the top of transmembrane region (TM) 7 and an epitope comprising the second extracellular loop (o2) of the M2 re...

We expressed the M2 gene in prokaryotic cells using the pAED4 expression vector system to produce native and purified M2 protein as a candidate for universal recombinant vaccine against influenza A subtypes. The open reading frame (ORF) of avian influenza A/chicken/Iran/101/1998 (H9N2) M2 gene was amplified by 2-step RT-PCR using specific primers and pfu DNA polymerase. pAED4 was used as expres...

A potential target for the development of universal vaccine strategies against Influenza A is the M2 protein - a membrane protein with a highly conserved extracellular domain. In this study we developed engineered T-cell receptors, by fusing M2-specific antibody sequences with T-cell receptor transmembrane and signaling domains to target influenza infected cells. When expressed on T-cells, thes...

We apply the K-correction to the black hole LMXB GX 339-4 which implies MX ≥ 6M⊙ by only assuming that the companion is more massive than ∼ 0.17M⊙, the lower limit allowed by applying a ’stripped-giant’ model. This evolutionary model successfully reproduces the observed properties of the system. We obtain a maximum mass for the companion of M2 ≤ 1.1M⊙ and an upper limit to the mass ratio of q(=...

Albumin concentration and body weight are altered in patients with multidrug-resistant tuberculosis (MDR-TB) and change during the long treatment period, potentially affecting drug disposition. We here describe the pharmacokinetics (PKs) of the novel anti-TB drug bedaquiline and its metabolite M2 in 335 patients with MDR-TB receiving 24 weeks of bedaquiline on top of a longer individualized bac...

Macrophages play a key role in the pathogenesis of liver granuloma and fibrosis in schistosomiasis. However, the underlying mechanisms have not been fully characterized. This study revealed that the macrophages infiltrating the liver tissues in a murine model of Schistosoma japonica infection exhibited M2 functional polarization, and Notch1/Jagged1 signaling was significantly upregulated in the...