Our previous study showed the early molecular responses of bone in response to obstructive nephropathy in a unilateral ureteral obstruction (UUO) mouse model. Here, we addressed the changes in trabecular bone properties at greater trochanter, the proximal and the distal metaphysis of femur in UUO mice. The male mice were subjected to UUO (n=10) or sham operation (n=10). All mice were killed on ...

Primary osteosarcoma of the bone with rhabdoid features is a rare malignant tumor of bone, not previously described in the literature. Here we report a 69-year-old female who originally presented with a right femur pathologic fracture. Radiographs of the injury showed an aggressive-appearing lesion of the distal femur. Initial biopsy was done, which was not diagnostic; additional advanced imagi...

The safety and effectiveness were examined of the spirulina alga on bone metabolism in ovariectomized estrogen-deficient rats and hindlimb-unloaded mice. The dosage range was from an amount equal to that recommended in so-called health foods for humans (0.08 g/kg BW/day) to a 100-fold higher dose. The bone mineral density (BMD) of the whole femur and tibia of ovariectomized rats in the any spir...

backgroundcongenital generalized lipodystrophy (cgl) is a rare disease. it is associated with near total fat loss, severe insulin resistance and hypoleptinemia leading to metabolic derangements.case presentationwe report a 25- year- old female with 1-acylglycerol-3-phosphate-o-acyltransferase 2 (apgat2) mutation, and both sclerotic and lytic bone lesions together for the first time. bone cyst i...

The effects of clodronate administered p.o. on bone mineral density (BMD), bone geometry and strength of bone were investigated in 6-month-old ovariectomized rats. Sixty Sprague-Dawley rats were randomized into four groups. Three groups were ovariectomized (OVX) and one group was sham-operated (SHAM). The OVX groups were given p.o. either clodronate (100 mg/kg/d or 500 mg/kg/d) or a vehicle. Th...

the aim of this study was to investigate the effect of high intensity interval training (hiit) on bone mass density in adult male wistar rats. for this purpose, 16 rats (weight 250±20 g and 6 weeks old) were divided into experimental group (n=8) and control group (n=8). after a week of orientation to the training protocol, 8 weeks of incremental hiit was performed. 24 hours after the last train...

Botulism is a generalized paralyzing disease caused by the toxin of Clostridium botulinum (BTX). The toxin acts 3-4 days after injection by blocking the release of acetylcholine to the muscle. Six Wistar rats received a 2-U injection of BTX in the right quadriceps. Six rats were similarly injected with saline and were used as control. Paralysis of the quadriceps was obtained 4-5 days after the ...

progressive loss of bone mineral density around the femora! component of total hip replacement continues to pose a threat to long term prosthetic survival. a linear study was undertaken to measure bone mineral density on a monthly basis following total hip arthroplasty in 11 male patients. the opposite femur was used as the control measurement. bone mineral density was unchanged at two months f...

We present a case of a 15-year-old boy with osteoblastic osteosarcoma of the left distal femur. The patient was referred to bone scan for initial staging. On planar bone scan, there is increased uptake of 99mTc-MDP (99mTc-methylene diphosphonate) in the left distal femur. There are also multiple sites of abnormal tracer uptake projecting to the thoracic cage, initially assumed to be localized i...