We synthesized polymorphic diamond directly from highly oriented pyrolytic graphite (HOPG) using femtosecond laser driven shock wave without catalyst. A femtosecond laser pulse (wavelength: 800 nm, pulse width: 120 fs, intensity: 2×10 W/cm) was irradiated onto the HOPG surface in air. Crystalline structures of HOPG after the laser irradiation were analyzed using the synchrotron X-ray at the BL1...

Next generation short pulse laser systems for high energy accelerator physics have been developed using novel synchronization techniques. The basic techniques are the synchronization of a mode locked oscillator to an RF reference, synchronization of two mode locked oscillators, synchronization of a lowrepetition amplifier to the oscillator, and multiplexing of modular laser beams. We have devel...

A study demonstrating how ultrafast laser radiation stimulates osteoblasts is presented. The study employed a custom made optical system that allowed for simultaneous confocal cell imaging and targeted femtosecond pulse laser irradiation. When femtosecond laser light was focused onto a single cell, a rise in intracellular Ca(2+) levels was observed followed by contraction of the targeted cell. ...

Femtosecond laser pulses have been widely used as a tool to study molecular ionization and fragmentation. This article bridges the application of femtosecond laser technology in early research focused on small isolated molecules with that in modern biological mass spectrometry for proteomics and metabolomic analysis on large (140+ atoms) biomolecules. The single-shot interaction of a femtosecon...

BACKGROUND Cataract surgery after penetratingkeratoplasty (PKP) is often challenging due to changes in the integrity of the cornea caused by PKP. For example, corneal endothelial cell (CEC) loss and corneal edema commonly occur after traditional phacoemulsification cataract surgery in patients that previously had successful PKP. Recent studies have reported that femtosecond laser-assisted catar...

Purpose: To report 2 cases that underwent deep anterior lamellar keratoplasty (DALK) and developed visually significant cataract and subsequently underwent femtosecond laser assisted cataract surgery (FLACS). Methods: Both patients underwent FLACS with implantation of toric intraocular lens (IOL) for correction of postkeratoplasty astigmatism. Capsulorrhexis was performed with the femtosecond l...

PURPOSE To compare the rates of rapid posterior capsule opacification (PCO) formation in the first 3 months following femtosecond laser-assisted cataract surgery (FLACS) to manual anterior capsulorhexis. METHODS Retrospective review of 29 cases of FLACS, comparing the rates of PCO in the first 3 months following surgery to 50 consecutive cases of manual anterior capsulorhexis. RESULTS Seven...

PURPOSE To report two cases of femtosecond laser-assisted small incision deep lamellar endothelial keratoplasty (DLEK) for patients with corneal endothelial decompensation by Fuchs dystrophy and glaucoma METHODS Femtosecond laser (IntraLase; IntraLase Corp., Irvine, CA) with 15 kHz of repetition rate, was used for a 9.5 mm diameter by 400 micrometer thickness donor corneal lamellar dissection...

We demonstrate rapid fabrication of complex three-dimensional (3D) microfluidic channels with lengths up to ~6.0 cm within a tiny volume down to ~80 nl in glass substrates by femtosecond laser direct writing, which, to the best of our knowledge, is the longest microfluidic channel directly embedded in glass by femtosecond laser microprocessing. The fabrication mainly includes the following two ...