نتایج جستجو برای: fat cell lipolysis

تعداد نتایج: 1789792  

Journal: :Diabetes 2016
Ingrid Dahlman Mikael Rydén David Brodin Harald Grallert Rona J Strawbridge Peter Arner

Central fat accumulation is a strong risk factor for type 2 diabetes. Genome-wide association studies have identified numerous loci associated with body fat distribution. The objectives of the current study are to examine whether genes in genetic loci linked to fat distribution can be linked to fat cell size and number (morphology) and/or adipose tissue function. We show, in a cohort of 114 wom...

Journal: :Discovery medicine 2006
K Alexander H Iwen Nina Perwitz Daniel Kraus Mathias Fasshauer Johannes Klein

Fat cells are traditionally considered dormant cells, quietly functioning in lipid accumulation and lipolysis. In recent years, fat cells received a glowing appraisal and were found to be an important player in energy homeostasis, tumorigenesis, immunity, and reproduction, via their endocrine and regulatory functions. Fat cells secrete adipokines, many of which are inflammation-related peptides...

Journal: :Poultry science 1996
T P Oscar

Adipocytes isolated from abdominal fat of female broilers and maintained in primary culture were used to characterize acute and chronic effects of somatostatin (SRIF) on lipolysis and antilipolysis and to determine whether desensitization and cross-regulation phenomena are involved in the regulation of adipocyte metabolism by SRIF and glucagon. Acute exposure of adipocytes to SRIF resulted in a...

Journal: :The Journal of biological chemistry 1971
T Kono F W Barham

The mechanism of the insulin-like action of trypsin was studied. When fat cells were exposed to trypsin (1 mg per ml) for 15 set, glucose metabolism in the cells was stimulated. This stimulation (like that by insulin) was inhibited by phloretin or 3-O-methyl-n-glucose. By the above treatment with trypsin, cellular lipolysis induced by epinephrine was blocked to a large extent, but that induced ...

Journal: :American journal of physiology. Endocrinology and metabolism 2005
Liping Hu Jude T Deeney Christopher J Nolan Marie-Line Peyot Ada Ao Ann Marie Richard Esthere Luc Nils J Faergeman Jens Knudsen Wen Guo Maria Sorhede-Winzell Marc Prentki Barbara E Corkey

Intracellular lipolysis is a major pathway of lipid metabolism that has roles, not only in the provision of free fatty acids as energy substrate, but also in intracellular signal transduction. The latter is likely to be particularly important in the regulation of insulin secretion from islet beta-cells. The mechanisms by which lipolysis is regulated in different tissues is, therefore, of consid...

Journal: :The American journal of physiology 1996
J Calles-Escandón M I Goran M O'Connell K S Nair E Danforth

The hypothesis that exercise increases fat oxidation at rest independently of changes in energy balance, body composition, and/or lipolysis was tested in 21 volunteers. After a period of energy balance, volunteers were randomly allocated to one of four groups: control, overfed (OF), overfed and exercised (OF-EX), and exercised (EX). OF and OF-EX were overfed 50% excess of energy balance calorie...

Journal: :American journal of physiology. Endocrinology and metabolism 2016
Ana Burgeiro Amelia Fuhrmann Sam Cherian Daniel Espinoza Ivana Jarak Rui A Carvalho Marisa Loureiro Miguel Patrício Manuel Antunes Eugénia Carvalho

Type 2 diabetes mellitus is a complex metabolic disease, and cardiovascular disease is a leading complication of diabetes. Epicardial adipose tissue surrounding the heart displays biochemical, thermogenic, and cardioprotective properties. However, the metabolic cross-talk between epicardial fat and the myocardium is largely unknown. This study sought to understand epicardial adipose tissue meta...

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