Fascioliasis is one of the public health problems in the world. Cysteine proteinases (CP) released by Fasciola gigantica play a key role in parasite feeding, migration through host tissues, and in immune evasion. There has been some evidence from several parasite systems that proteinases might have potential as protective antigens against parasitic infections. Cysteine proteinases were purified...

Gangguan penyakit pada ternak merupakan salah satu hambatan yang di hadapi dalam pengembangan peternakan. Di antara ini satunya adalah disebabkan oleh parasit cacing hati Fasciola spp. dikenal dengan nama Distomatosis, atau Fasciolosis. Diketahui telah ditemukanya F. intermedia dikarakterisasi berdasarkan morfologinya. Cacing ditemukan Pakistan dan Iran, hasil analisis gigantica dari memiliki k...

The epidemiology of trematode infections in cattle was investigated within highland and lowland areas of Iringa Rural District, in southern Tanzania. Fecal samples were collected from 450 cattle in 15 villages at altitudes ranging from 696 to 1800 m above the sea level. Freshwater snails were collected from selected water bodies and screened for emergence of cercariae. The infection rates in ca...

Metacercarial antigen of Fasciola gigantica was evaluated for early immunodiagnosis of experimental bovine fasciolosis using ELISA and Western blot. In ELISA, the experimental F. gigantica infection was detected as early as 2 weeks post-infection (WPI). The gradual increasing trend of antibody level was observed from 2 to 7 WPI, followed by a plateau, which was maintained up to 14 WPI. In Weste...

MF6p/FhHDM-1 is a small cationic heme-binding protein which is recognized by the monoclonal antibody (mAb) MF6, and abundantly present in parenchymal cells and secreted antigens of Fasciola hepatica. Orthologs of this protein (MF6p/HDMs) also exist in other causal agents of important foodborne trematodiasis, such as Clonorchis sinensis, Opisthorchis viverrini and Paragonimus westermani. Conside...

BACKGROUND In this study, we evaluated the biochemical, immunological, histopathological and antischistosomal activities of Schistosoma mansoni or Fasciola gigantica worm homogenates mixed either with or without saponin that was extracted from Atriplex nummularia. METHODOLOGY The immunization schedule was based on subcutaneous administration of two doses (50 microg /100 microl PBS) of each ho...

Saposin-like protein-2 (SAP-2) and leucine aminopeptidase (LAP) are major proteins involved in the digestive process of Fasciola gigantica (Fg). Both SAP-2 LAP highly expressed F. gigantica; therefore, they could be vaccine candidates for fasciolosis. The aims this study (1) to observe tissue expression (FgSAP-2) (FgLAP) by indirect immunofluorescence technique under confocal microscopy (2) tes...