Background—Although dysfunction of VE-cadherin–mediated adherence junctions in vascular endothelial cells (ECs) is thought to be one of the initial steps of atherosclerosis, little is known regarding how VE-cadherin is disrupted during atherogenic development. This study focused on the role of calpain, an intracellular cysteine protease, in the proteolytic disorganization of VE-cadherin and sub...

Objective. The purpose of this article is to explore the additive and moderating effects of neighborhood context on substance use among youth. Methods. Using a regional sample of adolescents and matching the data to Census tracts, we use hierarchical linear modeling to examine the relationship between neighborhood disadvantage and neighborhood instability on alcohol and marijuana use while cont...

This study focuses on healthcare for the elderly under the Family Health Strategy in three municipalities (counties) in the State of Rio de Janeiro, Brazil, specifically analyzing the organization of the healthcare network and the knowledge of six health teams, using interviews and focus groups. The study emphasized the central role of work by community health agents, the prioritization of prog...